{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:51:41Z","timestamp":1790614301840,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T00:00:00Z","timestamp":1305417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The virulence determinants of uropathogenic\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            have been studied extensively over the years, but relatively little is known about what differentiates isolates causing various types of urinary tract infections. In this study, we compared the genomic profiles of 45 strains from a range of different clinical backgrounds, i.e., urosepsis, pyelonephritis, cystitis, and asymptomatic bacteriuria (ABU), using comparative genomic hybridization analysis. A microarray based on 31 complete\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            sequences was used. It emerged that there is little correlation between the genotypes of the strains and their disease categories but strong correlation between the genotype and the phylogenetic group association. Also, very few genetic differences may exist between isolates causing symptomatic and asymptomatic infections. Only relatively few genes that could potentially differentiate between the individual disease categories were identified. Among these were two genomic islands, namely, pathogenicity island (PAI)-CFT073-\n            <jats:italic>serU<\/jats:italic>\n            and PAI-CFT073-\n            <jats:italic>pheU<\/jats:italic>\n            , which were significantly more associated with the pyelonephritis and urosepsis isolates than with the ABU and cystitis isolates. These two islands harbor genes encoding virulence factors, such as P fimbriae (pyelonephritis-associated fimbriae) and an important immunomodulatory protein, TcpC. It seems that both urovirulence and growth fitness can be attributed to an assortment of genes rather than to a specific gene set. Taken together, urovirulence and fitness are the results of the interplay of a mixture of factors taken from a rich menu of genes.\n          <\/jats:p>","DOI":"10.1128\/aem.02970-10","type":"journal-article","created":{"date-parts":[[2011,3,19]],"date-time":"2011-03-19T04:30:19Z","timestamp":1300509019000},"page":"3268-3278","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Comparative Genomics of Escherichia coli Strains Causing Urinary Tract Infections"],"prefix":"10.1128","volume":"77","author":[{"given":"Rebecca Munk","family":"Vejborg","sequence":"first","affiliation":[{"name":"DTU Food, Technical University of Denmark, Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Hancock","sequence":"additional","affiliation":[{"name":"DTU Food, Technical University of Denmark, Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Schembri","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Klemm","sequence":"additional","affiliation":[{"name":"DTU Food, Technical University of Denmark, Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.9.2915-2921.1991"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111640200"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600938103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.10.4555-4558.2000"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4641"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0161-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/004721-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01054-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27809-0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.641"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/011981-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01748-06"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2009.02542.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/319290"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.05.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/342490"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92743-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro818"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3541-3547.2000"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-2229.2010.00166.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01730-06"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.781-785.2006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02202.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/318710"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.34.3.920-929.1981"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1975.tb03860.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01717-08"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01744-06"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.5.1281-1289.1990"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3787"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01959-05"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00355.x"},{"key":"e_1_3_3_35_2","first-page":"1","article-title":"Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1997","volume":"13","author":"Schappert S. 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