{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:54:13Z","timestamp":1779288853813,"version":"3.51.4"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"the funds for creative research groups of China","award":["21621004"],"award-info":[{"award-number":["21621004"]}]},{"name":"the national key R&D program of China","award":["2017YFD0201405"],"award-info":[{"award-number":["2017YFD0201405"]}]},{"DOI":"10.13039\/501100001809","name":"the national natural science foundation of China","doi-asserted-by":"crossref","award":["31770076"],"award-info":[{"award-number":["31770076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,4,17]]},"abstract":"<jats:p>\n            As\n            <jats:sc>d<\/jats:sc>\n            -amino acids play an important role in cell wall synthesis, we analyzed the effects of 19 different\n            <jats:sc>d<\/jats:sc>\n            -amino acids on\n            <jats:named-content content-type=\"genus-species\">L. lactis<\/jats:named-content>\n            F44, demonstrating that\n            <jats:sc>d<\/jats:sc>\n            -Met and\n            <jats:sc>d<\/jats:sc>\n            -Phe can participate in peptidoglycan (PG) synthesis and improve the acid resistance and nisin yield of this strain.\n            <jats:italic>murF<\/jats:italic>\n            overexpression further increased the levels of\n            <jats:sc>d<\/jats:sc>\n            -Met and\n            <jats:sc>d<\/jats:sc>\n            -Phe incorporated into PG and contributed to the acid resistance of the strain. These findings suggest that\n            <jats:sc>d<\/jats:sc>\n            -Met and\n            <jats:sc>d<\/jats:sc>\n            -Phe can be incorporated into PG to improve the acid resistance and nisin yield of\n            <jats:named-content content-type=\"genus-species\">L. lactis<\/jats:named-content>\n            , and this study provides new ideas for the enhancement of nisin production.\n          <\/jats:p>","DOI":"10.1128\/aem.02981-19","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:12:10Z","timestamp":1582971130000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["<scp>d<\/scp>\n            -Methionine and\n            <scp>d<\/scp>\n            -Phenylalanine Improve Lactococcus lactis F44 Acid Resistance and Nisin Yield by Governing Cell Wall Remodeling"],"prefix":"10.1128","volume":"86","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ershu","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kairen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggele","family":"Caiyin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China"},{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China"},{"name":"SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0107-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9098-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2012.04.007"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-009-2217-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.00836.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7238"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-017-9268-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02483-17"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep27973"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-017-8365-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-018-2052-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2007.00094.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-13-S1-S9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05474.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504967112"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4137\/LPI.S31783"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.61"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0031"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00346"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06813.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178123"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.246"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.683342"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2040656"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2012.0009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.116.2.1029-1053.1973"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.17.5549-5559.1992"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12703.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600829103"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07684.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf01967563"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36244-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0571-8"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01540"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00511"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.791749"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00421-5"}],"container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.02981-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.02981-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T19:14:27Z","timestamp":1645643667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AEM.02981-19"}},"subtitle":[],"editor":[{"given":"Maia","family":"Kivisaar","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,4,17]]}},"alternative-id":["10.1128\/AEM.02981-19"],"URL":"https:\/\/doi.org\/10.1128\/aem.02981-19","relation":{},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]},"assertion":[{"value":"2019-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02981-19"}}