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Current therapeutic options rely on a limited repertoire of antifungals. Ergosterol is an essential component of the fungal cell membrane as well as a target of current antifungals. Approximately 20 enzymes are involved in ergosterol biosynthesis, of which acetyl-CoA acetyltransferase (ACAT) is the first enzyme. Two ACATs in\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    are\n                    <jats:italic>Af<\/jats:italic>\n                    Erg10A and\n                    <jats:italic>Af<\/jats:italic>\n                    Erg10B. However, the biological function of\n                    <jats:italic>Af<\/jats:italic>\n                    Erg10A is yet to be investigated. In this study, we showed that\n                    <jats:italic>Af<\/jats:italic>\n                    Erg10A is localized in the mitochondria and is essential for\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    survival and morphological development. In combination with structural studies, we validated\n                    <jats:italic>Af<\/jats:italic>\n                    Erg10A as a potential drug target that will facilitate the development of novel antifungals and improve the efficiency of existing drugs.\n                  <\/jats:p>","DOI":"10.1128\/aem.02986-19","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T04:41:02Z","timestamp":1580186462000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target"],"prefix":"10.1128","volume":"86","author":[{"given":"Yuanwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Centre for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, 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