{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:51:08Z","timestamp":1784778668342,"version":"3.55.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            spp. are highly differentiated actinomycetes with large, linear chromosomes that encode an arsenal of biologically active molecules and catabolic enzymes. Members of this genus are well equipped for life in nutrient-limited environments and are common soil saprophytes. Out of the hundreds of species in the genus\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            , a small group has evolved the ability to infect plants. The recent availability of\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            genome sequences, including four genomes of pathogenic species, provided an opportunity to characterize the gene content specific to these pathogens and to study phylogenetic relationships among them. Genome sequencing, comparative genomics, and phylogenetic analysis enabled us to discriminate pathogenic from saprophytic\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            strains; moreover, we calculated that the pathogen-specific genome contains 4,662 orthologs. Phylogenetic reconstruction suggested that\n            <jats:named-content content-type=\"genus-species\">Streptomyces scabies<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">S. ipomoeae<\/jats:named-content>\n            share an ancestor but that their biosynthetic clusters encoding the required virulence factor thaxtomin have diverged. In contrast,\n            <jats:named-content content-type=\"genus-species\">S. turgidiscabies<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">S. acidiscabies<\/jats:named-content>\n            , two relatively unrelated pathogens, possess highly similar thaxtomin biosynthesis clusters, which suggests that the acquisition of these genes was through lateral gene transfer.\n          <\/jats:p>","DOI":"10.1128\/aem.03504-15","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T03:58:42Z","timestamp":1454126322000},"page":"2146-2155","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Genome Content and Phylogenomics Reveal both Ancestral and Lateral Evolutionary Pathways in Plant-Pathogenic Streptomyces Species"],"prefix":"10.1128","volume":"82","author":[{"given":"Jose C.","family":"Huguet-Tapia","sequence":"first","affiliation":[{"name":"Department of Plant Pathology, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Lefebure","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Science, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Badger","sequence":"additional","affiliation":[{"name":"The J. Craig Venter Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg S.","family":"Pettis","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA"},{"name":"Department of Plant Pathology and Crop Physiology, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Stanhope","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Science, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Loria","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.40.110405.090639"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.06767-11"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00204-08"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/417141a"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211433198"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00005-07"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934677100"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.44.032905.091147"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00534-12"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-007-9205-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-008-9240-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-03-11-0073"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.738-744.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2010.11.002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04461.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2196"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.23.4636"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.5.0955"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1224503"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_22_2","unstructured":"Oksanen J Kindt R Legendre P O'Hara B. 2007. 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