{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:34:02Z","timestamp":1791178442469,"version":"4.1.0"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Members of the genus\n            <jats:named-content content-type=\"genus-species\">Flavobacterium<\/jats:named-content>\n            occur in a variety of ecological niches and represent an interesting diversity of lifestyles.\n            <jats:named-content content-type=\"genus-species\">Flavobacterium branchiophilum<\/jats:named-content>\n            is the main causative agent of bacterial gill disease, a severe condition affecting various cultured freshwater fish species worldwide, in particular salmonids in Canada and Japan. We report here the complete genome sequence of strain FL-15 isolated from a diseased sheatfish (\n            <jats:named-content content-type=\"genus-species\">Silurus glanis<\/jats:named-content>\n            ) in Hungary. The analysis of the\n            <jats:named-content content-type=\"genus-species\">F. branchiophilum<\/jats:named-content>\n            genome revealed putative mechanisms of pathogenicity strikingly different from those of the other, closely related fish pathogen\n            <jats:named-content content-type=\"genus-species\">Flavobacterium psychrophilum<\/jats:named-content>\n            , including the first cholera-like toxin in a non-\n            <jats:named-content content-type=\"genus-species\">Proteobacteria<\/jats:named-content>\n            and a wealth of adhesins. The comparison with available genomes of other\n            <jats:named-content content-type=\"genus-species\">Flavobacterium<\/jats:named-content>\n            species revealed a small genome size, large differences in chromosome organization, and fewer rRNA and tRNA genes, in line with its more fastidious growth. In addition, horizontal gene transfer shaped the evolution of\n            <jats:named-content content-type=\"genus-species\">F. branchiophilum<\/jats:named-content>\n            , as evidenced by its virulence factors, genomic islands, and CRISPR (clustered regularly interspaced short palindromic repeats) systems. Further functional analysis should help in the understanding of host-pathogen interactions and in the development of rational diagnostic tools and control strategies in fish farms.\n          <\/jats:p>","DOI":"10.1128\/aem.05625-11","type":"journal-article","created":{"date-parts":[[2011,9,17]],"date-time":"2011-09-17T02:06:58Z","timestamp":1316225218000},"page":"7656-7662","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Complete Genome Sequence of the Fish Pathogen Flavobacterium branchiophilum"],"prefix":"10.1128","volume":"77","author":[{"given":"Marie","family":"Touchon","sequence":"first","affiliation":[{"name":"Institut Pasteur, Microbial Evolutionary Genomics, D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, F-75015 Paris, France"},{"name":"CNRS, URA2171, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barbier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Virologie et Immunologie Mol\u00e9culaires, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bernardet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Virologie et Immunologie Mol\u00e9culaires, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Loux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Math\u00e9mathique, Informatique et G\u00e9nome, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Vacherie","sequence":"additional","affiliation":[{"name":"CEA\/DSV\/IG\/Genoscope, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Barbe","sequence":"additional","affiliation":[{"name":"CEA\/DSV\/IG\/Genoscope, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo P. 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