{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:46:03Z","timestamp":1791585963226,"version":"4.3.4"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In the present work, we report the characterization of a<jats:named-content content-type=\"genus-species\">Cryptosporidium parvum<\/jats:named-content>strain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone allogeneic stem cell transplantation. After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified as<jats:named-content content-type=\"genus-species\">C. parvum<\/jats:named-content>II2A15G2R1 (subtype linked to zoonotic exposure) and inoculated into SCID mice. In this host, this virulent<jats:named-content content-type=\"genus-species\">C. parvum<\/jats:named-content>isolate induced not only severe infection but also invasive gastrointestinal and biliary adenocarcinoma. The observation of adenocarcinomas that progressed through all layers of the digestive tract to the subserosa and spread via blood vessels confirmed the invasive nature of the neoplastic process. These results indicate for the first time that a human-derived<jats:named-content content-type=\"genus-species\">C. parvum<\/jats:named-content>isolate is able to induce digestive cancer. This study is of special interest considering the exposure of a large number of humans and animals to this waterborne protozoan, which is highly tumorigenic when inoculated in a rodent model.<\/jats:p>","DOI":"10.1128\/aem.06457-11","type":"journal-article","created":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T20:08:29Z","timestamp":1326571709000},"page":"1746-1751","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model"],"prefix":"10.1128","volume":"78","author":[{"given":"Gabriela","family":"Certad","sequence":"first","affiliation":[{"name":"Laboratory Biologie et Diversit\u00e9 des Pathog\u00e8nes Eucaryotes Emergents (BDEEP), Centre d'Infection et d'Immunit\u00e9 de Lille (CIIL), Institut Pasteur de Lille, INSERM U1019, CNRS UMR 8402, Universit\u00e9 Lille Nord de France, Lille, France"},{"name":"C\u00e1tedra de Parasitolog\u00eda, Escuela de Medicina Jos\u00e9 Mar\u00eda Vargas, Universidad Central de Venezuela (UCV), Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Benamrouz","sequence":"additional","affiliation":[{"name":"Laboratory Biologie et Diversit\u00e9 des Pathog\u00e8nes Eucaryotes Emergents (BDEEP), Centre d'Infection et d'Immunit\u00e9 de Lille (CIIL), Institut Pasteur de Lille, INSERM U1019, CNRS UMR 8402, Universit\u00e9 Lille Nord de France, Lille, France"},{"name":"Environnement et Sant\u00e9, FLST, Universit\u00e9 Catholique de Lille, Universit\u00e9 Lille Nord de France, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Guyot","sequence":"additional","affiliation":[{"name":"Laboratory Biologie et Diversit\u00e9 des Pathog\u00e8nes Eucaryotes Emergents (BDEEP), Centre d'Infection 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