{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:18Z","timestamp":1790937138267,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1983,1,1]],"date-time":"1983-01-01T00:00:00Z","timestamp":410227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p>\n            The mouse lethality test is the most sensitive method for confirming the diagnosis of infant botulism. Both\n            <jats:italic>Clostridium difficile<\/jats:italic>\n            and\n            <jats:italic>Clostridium botulinum<\/jats:italic>\n            produce heat-labile toxins which are lethal for mice and can be found in the feces of infants. These two toxins can be distinguished from one another in this assay when both are present in the same fecal specimen because they appear to be immunologically distinct toxins.\n          <\/jats:p>","DOI":"10.1128\/aem.45.1.347-349.1983","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T03:22:21Z","timestamp":1577848941000},"page":"347-349","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Differentiation of\n            <i>Clostridium difficile<\/i>\n            Toxin from\n            <i>Clostridium botulinum<\/i>\n            Toxin by the Mouse Lethality Test"],"prefix":"10.1128","volume":"45","author":[{"given":"Peter H.","family":"Gilligan","sequence":"first","affiliation":[{"name":"Microbiology Laboratories, St. Christopher's Hospital for Children,  and Departments of Pediatrics2 and Neurology, 3 Temple University School of Medicine, Philadelphia, Pennsylvania 19133; Bureau of Laboratories, State Department of Health and Human Welfare, Lionville, Pennsylvania 193534"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Brown","sequence":"additional","affiliation":[{"name":"Microbiology Laboratories, St. Christopher's Hospital for Children,  and Departments of Pediatrics2 and Neurology, 3 Temple University School of Medicine, Philadelphia, Pennsylvania 19133; Bureau of Laboratories, State Department of Health and Human Welfare, Lionville, Pennsylvania 193534"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Berman","sequence":"additional","affiliation":[{"name":"Microbiology Laboratories, St. Christopher's Hospital for Children,  and Departments of Pediatrics2 and Neurology, 3 Temple University School of Medicine, Philadelphia, Pennsylvania 19133; Bureau of Laboratories, State Department of Health and Human Welfare, Lionville, Pennsylvania 193534"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aem.45.1.347-349.1983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aem.45.1.347-349.1983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T20:31:59Z","timestamp":1645648319000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aem.45.1.347-349.1983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1128\/aem.45.1.347-349.1983"],"URL":"https:\/\/doi.org\/10.1128\/aem.45.1.347-349.1983","relation":{},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]},"assertion":[{"value":"1983-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}