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Overall, 94.1% of nymphs infected as larvae by feeding on rickettsemic guinea pigs died during the molt into adults and 88.3% of adult female ticks infected as nymphs died prior to feeding. In contrast, only 2.8% of uninfected larvae failed to develop into adults over two generations. Infected female ticks incubated at 4\u00b0C had a lower mortality (80.9%) than did those held at 21\u00b0C (96.8%). Rickettsiae were vertically transmitted to 39.0% of offspring, and significantly fewer larvae developed from infected ticks. The lethal effect of<jats:italic>R. rickettsii<\/jats:italic>may explain the low prevalence of infected ticks in nature and affect its enzootic maintenance.<\/jats:p>","DOI":"10.1128\/aem.65.2.773-778.1999","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T19:47:12Z","timestamp":1576784832000},"page":"773-778","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":188,"title":["Lethal Effect of<i>Rickettsia rickettsii<\/i>on Its Tick Vector (<i>Dermacentor andersoni<\/i>)"],"prefix":"10.1128","volume":"65","author":[{"given":"Mark L.","family":"Niebylski","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mort G.","family":"Peacock","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G.","family":"Schwan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"423","article-title":"Observations on the mechanism of the transmission of plague by fleas.","volume":"3","author":"Bacot A. 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