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The mechanism of their enzymatic oxidation was studied with seven fungal laccases. The oxidation had a bell-shaped pH-activity profile with an optimal pH ranging from 4 to 7. The oxidation rate was found to be dependent on the redox potential difference between the N-OH substrate and laccase. A laccase with a higher redox potential or an N-OH compound with a lower redox potential tended to have a higher oxidation rate. Similar to the enzymatic oxidation of phenols, phenoxazines, phenothiazines, and other redox-active compounds, an \u201couter-sphere\u201d type of single-electron transfer from the substrate to laccase and proton release are speculated to be involved in the rate-limiting step for N-OH oxidation.<\/jats:p>","DOI":"10.1128\/aem.66.5.2052-2056.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:56:57Z","timestamp":1027749417000},"page":"2052-2056","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":257,"title":["Redox Chemistry in Laccase-Catalyzed Oxidation of N-Hydroxy Compounds"],"prefix":"10.1128","volume":"66","author":[{"given":"Feng","family":"Xu","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Novo Nordisk Biotech, Davis, California 956161;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juozas J.","family":"Kulys","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute of Biochemistry, Mokslininku 12, 2600 Vilnius, Lithuania2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Duke","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Novo Nordisk Biotech, Davis, California 956161;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichang","family":"Li","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Forest Products, Oregon State University, Corvallis, Oregon 973313; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kastis","family":"Krikstopaitis","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute of Biochemistry, Mokslininku 12, 2600 Vilnius, Lithuania2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz-Josef W.","family":"Deussen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Novo Nordisk A\/S, Novo Alle\u0301, DK-2880 Bagsv\u00e6rd, Denmark4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Abbate","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Novo Nordisk Biotech, Davis, California 956161;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilija","family":"Galinyte","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute of Biochemistry, Mokslininku 12, 2600 Vilnius, Lithuania2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Schneider","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Novo Nordisk A\/S, Novo Alle\u0301, DK-2880 Bagsv\u00e6rd, Denmark4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01300-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008813206178"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0728(86)90222-6"},{"key":"e_1_3_2_5_2","first-page":"1537","article-title":"Aminyloxide (Nitroxide). 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