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In\n            <jats:italic>C. aminovalericum<\/jats:italic>\n            , a gene encoding a previously characterized H\n            <jats:sub>2<\/jats:sub>\n            O-forming NADH oxidase, designated\n            <jats:italic>noxA<\/jats:italic>\n            , was cloned and sequenced. The expression of\n            <jats:italic>noxA<\/jats:italic>\n            was strongly upregulated within 10 min after the growth conditions were altered to a microoxic state, indicating that\n            <jats:italic>C. aminovalericum<\/jats:italic>\n            NoxA is involved in oxygen metabolism. In\n            <jats:italic>C. acetobutylicum<\/jats:italic>\n            , genes suggested to be involved in oxygen metabolism and genes for reactive oxygen species (ROS) scavenging were chosen from the genome database. Although no clear orthologue of\n            <jats:italic>C. aminovalericum<\/jats:italic>\n            NoxA was found, Northern blot analysis identified many O\n            <jats:sub>2<\/jats:sub>\n            -responsive genes (e.g., a gene cluster [\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC2448\">CAC2448<\/jats:ext-link>\n            to\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC2452\">CAC2452<\/jats:ext-link>\n            ] encoding an NADH rubredoxin oxidoreductase-A-type flavoprotein-desulfoferrodoxin homologue-MerR family-like protein-flavodoxin, an operon [\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC1547\">CAC1547<\/jats:ext-link>\n            to\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC1549\">CAC1549<\/jats:ext-link>\n            ] encoding a thioredoxin-thioredoxin reductase-glutathione peroxidase-like protein, an operon [\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC1570\">CAC1570<\/jats:ext-link>\n            and\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"gen\" xlink:href=\"CAC1571\">CAC1571<\/jats:ext-link>\n            ] encoding two glutathione peroxidase-like proteins, and genes encoding thiol peroxidase, bacterioferritin comigratory proteins, and superoxide dismutase) whose expression was quickly and synchronously upregulated within 10 min after flushing with 5% O\n            <jats:sub>2.<\/jats:sub>\n            The corresponding enzyme activities, such as NAD(P)H-dependent peroxide (H\n            <jats:sub>2<\/jats:sub>\n            O\n            <jats:sub>2<\/jats:sub>\n            and alkyl hydroperoxides) reductase, were highly induced, indicating that microoxic growth of\n            <jats:italic>C. acetobutylicum<\/jats:italic>\n            is associated with the expression of a number of genes for oxygen metabolism and ROS scavenging.\n          <\/jats:p>","DOI":"10.1128\/aem.71.12.8442-8450.2005","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T11:07:48Z","timestamp":1133867268000},"page":"8442-8450","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":88,"title":["Adaptive Responses to Oxygen Stress in Obligatory Anaerobes\n            <i>Clostridium acetobutylicum<\/i>\n            and\n            <i>Clostridium aminovalericum<\/i>"],"prefix":"10.1128","volume":"71","author":[{"given":"Shinji","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Biosciences, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watamura","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Tokyo University of Agriculture, 196 Yasaka, Abashiri 099-2493, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Niimura","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46956-6"},{"key":"e_1_3_2_3_2","first-page":"27","volume":"3","year":"1991","unstructured":"Andreesen, J. 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