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Mechanical forces resulting from fluid flow are often present under in vivo conditions, and it is commonly presumed that fluid flow will further add to the inhibitive effect seen under static conditions. In striking contrast, we discover that when surface adhesion is mediated by catch bonds, whose bond life increases with increased applied force, shear stress may dramatically increase the ability of bacteria to withstand detachment by soluble competitive inhibitors. This shear stress-induced protection against inhibitor-mediated detachment is shown here for the fimbrial FimH-mannose-mediated surface adhesion of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            . Shear stress-enhanced reduction of bacterial detachment has major physiological and therapeutic implications and needs to be considered when developing and screening drugs.\n          <\/jats:p>","DOI":"10.1128\/aem.72.4.3005-3010.2006","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T13:43:49Z","timestamp":1144331029000},"page":"3005-3010","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Elevated Shear Stress Protects\n            <i>Escherichia coli<\/i>\n            Cells Adhering to Surfaces via Catch Bonds from Detachment by Soluble Inhibitors"],"prefix":"10.1128","volume":"72","author":[{"given":"Lina M.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology, ETH Ho\u0308nggerberg, CH-8093 Zu\u0308rich, Switzerland"},{"name":"Departments of Bioengineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy E.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeni V.","family":"Sokurenko","sequence":"additional","affiliation":[{"name":"Microbiology, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Vogel","sequence":"additional","affiliation":[{"name":"Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology, ETH Ho\u0308nggerberg, CH-8093 Zu\u0308rich, Switzerland"},{"name":"Departments of Bioengineering"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.347575"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04415.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6462"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404387200"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199708)36:2<152::AID-JBM3>3.0.CO;2-J"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(99)00108-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.2.472-476.1987"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl049329z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(94)84015-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0075fje"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02915.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.10.005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm049476"},{"key":"e_1_3_2_15_2","first-page":"71","volume":"27","year":"1992","unstructured":"Karlsson, K. 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