{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:28:45Z","timestamp":1767166125751,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1968,2,1]],"date-time":"1968-02-01T00:00:00Z","timestamp":-60480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1968,2]]},"abstract":"<jats:p>\n                    Hemolytic\n                    <jats:italic>Haemophilus<\/jats:italic>\n                    are rarely isolated in the clinical laboratory, as they do not grow on sheep or human blood-agar alone. On rabbit blood-agar they grow well and are hemolytic, but they grow less well and are not hemolytic on sheep blood-agar with added X and V factors. A survey was made to determine their incidence in pharyngitis. From 28 of 100 sore throats and from 57 of 100 normal throats, only normal bacterial flora were isolated. \u03b2-Streptococci were present in significant numbers in 9 sore and 11 normal throats; staphylococci in 8 sore and 4 normal throats; pneumococci in 20 sore and 11 normal throats;\n                    <jats:italic>H. influenzae<\/jats:italic>\n                    or\n                    <jats:italic>H. parainfluenzae<\/jats:italic>\n                    in 13 sore and no normal throats; hemolytic\n                    <jats:italic>Haemophilus<\/jats:italic>\n                    in 30 sore and 18 normal throats; enteric bacilli in 1 of each;\n                    <jats:italic>Candida<\/jats:italic>\n                    and\n                    <jats:italic>Neisseria<\/jats:italic>\n                    in 2 sore throats each. All of the 33 hemolytic\n                    <jats:italic>Haemophilus<\/jats:italic>\n                    isolates identified to species were\n                    <jats:italic>H. parahaemolyticus<\/jats:italic>\n                    . All were sensitive in vitro to chloramphenicol, erythromycin, and tetracycline; 30 were sensitive to ampicillin and 30 to penicillin, 26 to novobiocin, and 12 to methicillin.\n                    <jats:italic>H. influenzae, H. parainfluenzae<\/jats:italic>\n                    , and\n                    <jats:italic>H. haemolyticus<\/jats:italic>\n                    are indistinguishable by Gram stain morphology, but\n                    <jats:italic>H. parahaemolyticus<\/jats:italic>\n                    is larger than the other three. Hemolytic and nonhemolytic species are indistinguishable by colonial morphology or by nutritional requirements; only hemolysis gives positive differentiation. Nevertheless, only rarely would this be of clinical importance.\n                    <jats:italic>H. parahaemolyticus<\/jats:italic>\n                    apparently may cause pharyngitis, but it is almost always susceptible to penicillin and rarely if ever causes sequelae.\n                  <\/jats:p>","DOI":"10.1128\/am.16.2.256-259.1968","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:50:38Z","timestamp":1607140238000},"page":"256-259","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Bacteriology and Clinical Significance of Hemolytic\n                    <i>Haemophilus<\/i>\n                    in the Throat"],"prefix":"10.1128","volume":"16","author":[{"given":"Dorothy","family":"Branson","sequence":"first","affiliation":[{"name":"Columbia Hospital, Milwaukee, Wisconsin 53211"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.16.2.256-259.1968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.16.2.256-259.1968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T03:27:57Z","timestamp":1645586877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.16.2.256-259.1968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,2]]},"references-count":0,"aliases":["10.1128\/aem.16.2.256-259.1968"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,2]]}},"alternative-id":["10.1128\/am.16.2.256-259.1968"],"URL":"https:\/\/doi.org\/10.1128\/am.16.2.256-259.1968","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1968,2]]},"assertion":[{"value":"1968-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}