{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:03:39Z","timestamp":1767164619876,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1970,1,1]],"date-time":"1970-01-01T00:00:00Z","timestamp":0},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1970,1]]},"abstract":"<jats:p>\n                    We demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10\n                    <jats:sup>9.8<\/jats:sup>\n                    mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects.\n                  <\/jats:p>","DOI":"10.1128\/am.19.1.196-198.1970","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:41:21Z","timestamp":1607139681000},"page":"196-198","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Growth of Venezuelan Equine Encephalomyelitis Virus in Human Diploid Cell Strain WI-38"],"prefix":"10.1128","volume":"19","author":[{"given":"Morton","family":"Reitman","sequence":"first","affiliation":[{"name":"Immunology II Branch, MI Division, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Green","sequence":"additional","affiliation":[{"name":"Immunology II Branch, MI Division, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.19.1.196-198.1970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.19.1.196-198.1970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T05:16:19Z","timestamp":1645593379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.19.1.196-198.1970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1]]},"references-count":0,"aliases":["10.1128\/aem.19.1.196-198.1970"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,1]]}},"alternative-id":["10.1128\/am.19.1.196-198.1970"],"URL":"https:\/\/doi.org\/10.1128\/am.19.1.196-198.1970","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1970,1]]},"assertion":[{"value":"1970-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}