{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:45:27Z","timestamp":1767167127848,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1970,2,1]],"date-time":"1970-02-01T00:00:00Z","timestamp":2678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1970,2]]},"abstract":"<jats:p>\n                    Germ-free guinea pigs died with signs and lesions of acute enterotoxemia after oral ingestion of\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    types B, C, D, and E. The signs and lesions observed resembled those seen in acute enterotoxemia of sheep and cattle and the naturally occurring disease seen in \u201cex-germ-free\u201d guinea pigs.\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    type A was found to be innocuous. Conventional guinea pigs did not become ill after ingestion of any of the five toxigenic types.\n                  <\/jats:p>","DOI":"10.1128\/am.19.2.314-316.1970","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:41:29Z","timestamp":1607139689000},"page":"314-316","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Pathogenicity of\n                    <i>Clostridium perfringens<\/i>\n                    for Germ-Free Guinea Pigs After Oral Ingestion"],"prefix":"10.1128","volume":"19","author":[{"given":"Richard E.","family":"Horton","sequence":"first","affiliation":[{"name":"Laboratory of Microbial Immunity, and Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Madden","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Immunity, and Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman B.","family":"McCullough","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Immunity, and Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.19.2.314-316.1970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.19.2.314-316.1970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T05:42:42Z","timestamp":1645594962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.19.2.314-316.1970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,2]]},"references-count":0,"aliases":["10.1128\/aem.19.2.314-316.1970"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,2]]}},"alternative-id":["10.1128\/am.19.2.314-316.1970"],"URL":"https:\/\/doi.org\/10.1128\/am.19.2.314-316.1970","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1970,2]]},"assertion":[{"value":"1970-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}