{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:16:18Z","timestamp":1790241378919,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1970,7,1]],"date-time":"1970-07-01T00:00:00Z","timestamp":15638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1970,7]]},"abstract":"<jats:p>\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            cells that are initially susceptible to cephalexin can be induced to acquire intrinsic resistance to cephalexin in comparatively few steps. Concomitantly, resistance to cephalothin, oxacillin, and dicloxacillin increases. By population analysis, there is heteroresistance to cephalexin in some strains of\n            <jats:italic>S. aureus.<\/jats:italic>\n            Heterogeneity in colonial morphology on prolonged incubation in the presence of subinhibitory concentrations of cephalexin may constitute an expression of such heteroresistance.\n          <\/jats:p>","DOI":"10.1128\/am.20.1.1-5.1970","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T09:28:44Z","timestamp":1607160524000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Acquired and Native Resistance of\n            <i>Staphylococcus aureus<\/i>\n            to Cephalexin and Other \u03b2-Lactam Antibiotics"],"prefix":"10.1128","volume":"20","author":[{"given":"Fritz H.","family":"Kayser","sequence":"first","affiliation":[{"name":"Section of Infectious and Immunologic Diseases, Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Jack","family":"Benner","sequence":"additional","affiliation":[{"name":"Section of Infectious and Immunologic Diseases, Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Hoeprich","sequence":"additional","affiliation":[{"name":"Section of Infectious and Immunologic Diseases, Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.20.1.1-5.1970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.20.1.1-5.1970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T11:10:44Z","timestamp":1645614644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.20.1.1-5.1970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,7]]},"references-count":0,"aliases":["10.1128\/aem.20.1.1-5.1970"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,7]]}},"alternative-id":["10.1128\/am.20.1.1-5.1970"],"URL":"https:\/\/doi.org\/10.1128\/am.20.1.1-5.1970","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1970,7]]},"assertion":[{"value":"1970-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}