{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:35:32Z","timestamp":1789425332969,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>\n            A dosage equal to or greater than approximately 3.4 Dex (decimal exponent, log\n            <jats:sub>10<\/jats:sub>\n            ) weanling mouse intracerebral 50% lethal dose (LD\n            <jats:sub>50<\/jats:sub>\n            ) was sufficient to elicit a yellow fever antibody response, as determined by the plaque neutralization (PN) test, in better than 90% of vaccinated rhesus monkeys. Lower dosages were progressively less effective in terms of PN titers and the PN and hemagglutination-inhibition serological conversion rates observed. A dose of between 3.4 and 4.2 Dex weanling mouse intracerebral LD\n            <jats:sub>50<\/jats:sub>\n            , or one-tenth to one times the dosage recommended for man, provided an optimal antibody response in monkeys. In rhesus monkeys, in contrast to the findings for man, pre-existing yellow fever antibody did not interfere with the antibody response to yellow fever vaccine. The PN test was felt to be a more sensitive and specific indicator of yellow fever antibody in rhesus monkeys after vaccination than the hemagglutination inhibition or complement fixation tests.\n          <\/jats:p>","DOI":"10.1128\/am.23.5.908-913.1972","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T09:22:29Z","timestamp":1607160149000},"page":"908-913","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Yellow Fever Vaccine. V. Antibody Response in Monkeys Inoculated with Graded Doses of the 17D Vaccine"],"prefix":"10.1128","volume":"23","author":[{"given":"Richard A.","family":"Mason","sequence":"first","affiliation":[{"name":"Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"Tauraso","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Ginn","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy W.","family":"Trimmer","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.23.5.908-913.1972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.23.5.908-913.1972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T13:15:32Z","timestamp":1645622132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.23.5.908-913.1972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":0,"aliases":["10.1128\/aem.23.5.908-913.1972"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1128\/am.23.5.908-913.1972"],"URL":"https:\/\/doi.org\/10.1128\/am.23.5.908-913.1972","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1972,5]]},"assertion":[{"value":"1972-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}