{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:04:02Z","timestamp":1767164642158,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1972,8,1]],"date-time":"1972-08-01T00:00:00Z","timestamp":81475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1972,8]]},"abstract":"<jats:p>\n                    Experiments were designed to evaluate a Microtiter latex agglutination (Micro-LA) test, as a serological aid in the diagnosis of histoplasmosis, and to compare this test with the conventional microtiter-complement fixation (CF) test for histoplasmosis. Sera tested were from cases of acute and chronic pulmonary and disseminated histoplasmosis, as well as from individuals not having histoplasmosis. Ninety-seven percent of the cases of acute pulmonary histoplasmosis had positive Micro-LA tests, whereas 91% had positive CF tests. Ninety-six percent of the patients having chronic pulmonary histoplasmosis showed positive Micro-LA tests and 91% had positive CF tests. In contrast, 64% of the cases of disseminated histoplasmosis had positive Micro-LA tests, whereas 82% had positive CF tests. None of these differences was statistically significant. Although there were no significant differences in complement fixing and agglutinating antibody cross-reactivity with\n                    <jats:italic>Blastomyces<\/jats:italic>\n                    antigens, more patients demonstrated CF titers than Micro-LA titers. Sera from patients with acute and chronic histoplasmosis showed higher Micro-LA titers than CF titers, whereas sera from cases of disseminated histoplasmosis showed higher CF titers. Histoplasmin skin testing has less of a boosting effect on agglutinating antibodies than on CF antibodies to histoplasmin. Anticomplementary sera can be used in the Micro-LA test. This test is simple to perform, and results can be obtained in 2 to 4 hr.\n                  <\/jats:p>","DOI":"10.1128\/am.24.2.191-197.1972","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T04:23:09Z","timestamp":1607142189000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of a Microtiter Latex Agglutination Test for Histoplasmosis"],"prefix":"10.1128","volume":"24","author":[{"given":"Jay D.","family":"Gerber","sequence":"first","affiliation":[{"name":"Ecological Investigations Program, Center for Disease Control, Health Services and Mental Health Administration, Kansas City, Kansas 66103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Riley","sequence":"additional","affiliation":[{"name":"Ecological Investigations Program, Center for Disease Control, Health Services and Mental Health Administration, Kansas City, Kansas 66103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Jones","sequence":"additional","affiliation":[{"name":"Ecological Investigations Program, Center for Disease Control, Health Services and Mental Health Administration, Kansas City, Kansas 66103"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.24.2.191-197.1972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.24.2.191-197.1972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:18:04Z","timestamp":1645604284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.24.2.191-197.1972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,8]]},"references-count":0,"aliases":["10.1128\/aem.24.2.191-197.1972"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,8]]}},"alternative-id":["10.1128\/am.24.2.191-197.1972"],"URL":"https:\/\/doi.org\/10.1128\/am.24.2.191-197.1972","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1972,8]]},"assertion":[{"value":"1972-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}