{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:31:22Z","timestamp":1767166282124,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1973,5,1]],"date-time":"1973-05-01T00:00:00Z","timestamp":105062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1973,5]]},"abstract":"<jats:p>Mice vaccinated with a single injection of formalin-inactivated suspensions of mouse brain tissue infected with arboviruses were markedly protected against a challenge injection administered hours later. The protection observed during the first 2 days after vaccination seemed to be nonspecific, in that it appeared not only with the homologous system but also between arboviruses of different antigenic groups; this phase may be associated with an interferon-like activity of the serum. Overlapping the nonspecific phase was one of specific protection, which seemed to be well-established in its own right by day 3 or 4 after vaccination. Serum neutralizing antibodies against the homologous viruses were detected as early as 24 h after vaccination and in almost all instances by day 3.<\/jats:p>","DOI":"10.1128\/am.25.5.755-762.1973","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T04:25:08Z","timestamp":1607142308000},"page":"755-762","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Resistance to Arbovirus Challenge in Mice Immediately After Vaccination"],"prefix":"10.1128","volume":"25","author":[{"given":"Jordi","family":"Casals","sequence":"first","affiliation":[{"name":"Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja M.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Barry","sequence":"additional","affiliation":[{"name":"Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.25.5.755-762.1973","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.25.5.755-762.1973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:53:23Z","timestamp":1645606403000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.25.5.755-762.1973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5]]},"references-count":0,"aliases":["10.1128\/aem.25.5.755-762.1973"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,5]]}},"alternative-id":["10.1128\/am.25.5.755-762.1973"],"URL":"https:\/\/doi.org\/10.1128\/am.25.5.755-762.1973","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1973,5]]},"assertion":[{"value":"1973-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}