{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:37:43Z","timestamp":1767166663703,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1961,7,1]],"date-time":"1961-07-01T00:00:00Z","timestamp":-268358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Microbiol"],"published-print":{"date-parts":[[1961,7]]},"abstract":"<jats:p>Rifomycin complex, a mixture of at least five different antibiotic principles, has been produced by submerged fermentation procedures in the laboratory and on pilot plant scale, using a semisynthetic medium. Difficulties were met with, due to the heterogeneity of the antibiotic principles. Mutation work led to the isolation of a strain that produced fractions C and D in greater amounts.<\/jats:p>","DOI":"10.1128\/am.9.4.320-324.1961","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T04:52:02Z","timestamp":1607143922000},"page":"320-324","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Rifomycin"],"prefix":"10.1128","volume":"9","author":[{"given":"P.","family":"Margalith","sequence":"first","affiliation":[{"name":"Research Laboratories, Lepetit S.p.A., Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Research Laboratories, Lepetit S.p.A., Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.9.4.320-324.1961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/am.9.4.320-324.1961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T23:08:03Z","timestamp":1645571283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/am.9.4.320-324.1961"}},"subtitle":["XIII. Fermentation and Production of Rifomycin Complex"],"short-title":[],"issued":{"date-parts":[[1961,7]]},"references-count":0,"aliases":["10.1128\/aem.9.4.320-324.1961"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[1961,7]]}},"alternative-id":["10.1128\/am.9.4.320-324.1961"],"URL":"https:\/\/doi.org\/10.1128\/am.9.4.320-324.1961","relation":{},"ISSN":["0003-6919"],"issn-type":[{"value":"0003-6919","type":"print"}],"subject":[],"published":{"date-parts":[[1961,7]]},"assertion":[{"value":"1961-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}