{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:30:08Z","timestamp":1787016608410,"version":"build-2736575974"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n \n Helicobacter pylori<\/jats:italic>\n was first isolated from humans in 1983. Since then, >50\n Helicobacter<\/jats:italic>\n species have been registered.\n Helicobacter trogontum<\/jats:italic>\n was first isolated from rat colonic mucosa in 1996 and has been isolated from pig feces and the livers of aborted sheep.\n H. trogontum<\/jats:italic>\n adheres to and invades human cells and secretes factors that may contribute to disease development.\n <\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n A 41-year-old woman, who worked on a pig farm, presented to our hospital with sudden-onset headache, nausea, general fatigue, chills, and fever. Plain computed tomography revealed small lymph nodes in the ileocecal region. Intravenous ceftriaxone, vancomycin, and acyclovir were administered for suspected meningoencephalitis. She was discharged from the hospital on day 9 after her symptoms improved. The cerebrospinal fluid culture was negative. However, an aerobic bottle was positive in one of two blood culture sets. Microscopic examination with Gram staining revealed fusiform gram-negative bacteria. Whole genome sequencing of the NHP16-4001 isolate confirmed\n H. trogontum<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Case reports of human infection with\n H. trogontum<\/jats:italic>\n are rare. However,\n H. trogontum<\/jats:italic>\n has been reported to cause enterocolitis and sepsis in an immunocompetent human, and skin lesions as well as bacteremia in an immunocompromised human.\n H. trogontum<\/jats:italic>\n was isolated from pigs, sheep, and mice, suggesting its potential importance as a zoonotic disease. In this case, we hypothesize that bacteremia development was related to contact with pig feces on the patient\u2019s farm. Thus,\n H. trogontum<\/jats:italic>\n infection may be considered a zoonosis; however, further reports are warranted for arriving at a definitive conclusion.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00002-25","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:00:51Z","timestamp":1752066051000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Bacteremia caused by\n Helicobacter trogontum<\/i>\n indicative of zoonotic infection in a pig farmer: a case report"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-0101","authenticated-orcid":true,"given":"Nobumasa","family":"Hojo","sequence":"first","affiliation":[{"name":"Department of General Medicine, NHO Hamada Medical Center","place":["Hamada City, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Unehara","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/041c01c38","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Laboratory, NHO Okayama Medical Center","place":["Okayama City, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-2193","authenticated-orcid":false,"given":"Masato","family":"Suzuki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001ggbx22","id-type":"ROR","asserted-by":"publisher"}],"name":"Antimicrobial Resistance Research Center, National Institute of Infectious Diseases","place":["Tokyo, 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