{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:38:26Z","timestamp":1785411506123,"version":"3.56.0"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n \n Background<\/jats:bold>\n <\/jats:title>\n \n Mycetohabitans<\/jats:italic>\n [\n Burkholderia<\/jats:italic>\n ]\n rhizoxinica<\/jats:italic>\n is an endosymbiotic bacteria of\n Rhizopus microsporus<\/jats:italic>\n that normally causes rice seedling blight. In our case report, we present one of the first known cases of concomitant bacteremia with\n M. rhizoxinica<\/jats:italic>\n and invasive mold infection due to\n Rhizopus<\/jats:italic>\n spp. in an immunocompromised child.\n <\/jats:p>\n <\/jats:sec>\n \n \n Case Summary<\/jats:bold>\n <\/jats:title>\n \n A 3 year old male recently diagnosed with B-cell acute lymphoblastic leukemia developed febrile neutropenia. His workup was significant for invasive fungal sinusitis due to\n Exserohilum<\/jats:italic>\n spp. based on histopathology and culture, a right middle lobe infiltrate, and a blood culture positive for gram-negative coccobacilli, later identified as\n M. rhizoxinica<\/jats:italic>\n . Additionally, metagenomics next-generation sequencing was positive for\n R. microsporus<\/jats:italic>\n as was broad-range fungal PCR testing of a lung biopsy sample. His surgical treatments included sinus debridement and a near total right pneumonectomy, and his antimicrobial treatment included 10 days of cefepime for his bacteremia, 4 weeks of liposomal amphotericin B, 4 weeks of micafungin following his pneumonectomy, and approximately 12 months of posaconazole.\n <\/jats:p>\n <\/jats:sec>\n \n \n Conclusion<\/jats:bold>\n <\/jats:title>\n \n This case highlights the association of\n M. rhizoxinica<\/jats:italic>\n with\n Rhizopus<\/jats:italic>\n spp., wherein the isolation of\n M. rhizoxinica<\/jats:italic>\n led to a high index of suspicion of\n Rhizopus<\/jats:italic>\n infection in an immunocompromised patient who developed bacteremia with a slow-growing, oxidase positive, gram-negative bacteria not able to be identified by traditional identification methods.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00014-24","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T09:01:20Z","timestamp":1743584480000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Mycetohabitans rhizoxinica<\/i>\n bacteremia in the setting of invasive fungal disease in an immunocompromised patient"],"prefix":"10.1128","volume":"1","author":[{"given":"Marisa","family":"Orbea","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pttbw34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine and Texas Children\u2019s Hospital","place":["Houston, 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L.","family":"Palazzi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pttbw34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine and Texas Children\u2019s Hospital","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-281X","authenticated-orcid":true,"given":"James J.","family":"Dunn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pttbw34","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Baylor College of Medicine and Texas Children\u2019s Hospital","place":["Houston, 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D.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1128\/asmcr.00014-24"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00014-24","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00014-24"}}