{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:14:45Z","timestamp":1757625285403,"version":"3.44.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n \n Legionella cardiaca<\/jats:italic>\n is a Gram-negative bacterium initially isolated from the heart valve of a patient with endocarditis. Since its species description in 2012, there have been no other report of infections.\n <\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n Here, we describe two cases of\n L. cardiaca<\/jats:italic>\n pneumonia. The patients were a 74-year-old man from New Orleans, Louisiana, USA, with underlying multiple myeloma and a 67-year-old man from Oklahoma City, Oklahoma, USA, with chronic lymphocytic leukemia. They developed cough and fever while undergoing antineoplastic therapy in August 2022 and July 2024, respectively. Laboratory examinations showed leukocytosis in the man with multiple myeloma and pancytopenia in the other with leukemia. In both patients, chest computed tomography showed ground-glass and consolidative opacities in the lung fields to suggest pneumonia. The cultures of the bronchoalveolar lavage fluids grew slender Gram-negative bacilli on buffered charcoal yeast extract (BCYE) agar with growth dependence on L-cysteine. The bacilli were identified by sequencing analyses of the 16S rRNA gene and Mip gene as\n L. cardiaca<\/jats:italic>\n . The patients were treated with a combination of cefepime and other antibiotics and recovered. Both cases were sporadic infections, with likely exposure in the patients\u2019 hometowns of New Orleans and Oklahoma City, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These results suggest that\n L. cardiaca<\/jats:italic>\n is an opportunistic pathogen and may cause pneumonia, or Legionnaires\u2019 disease, in immunocompromised patients. Culture with BCYE agar and gene sequencing analysis may be required to recover and identify the bacterium for an etiologic diagnosis.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00043-24","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T09:02:36Z","timestamp":1733994156000},"source":"Crossref","is-referenced-by-count":0,"title":["Two cases of Legionnaires\u2019 disease due to\n Legionella cardiaca<\/i>"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-0870","authenticated-orcid":true,"given":"Xiang Y.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Bowman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-5825","authenticated-orcid":true,"given":"Micah M.","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diwaker","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4801-3.00234-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.506-526.2002"},{"key":"e_1_3_2_4_2","unstructured":"LPSN \u2013 List of Prokaryotic names with Standing in Nomenclature. Maintained by German Collections of Microorganisms and Cell Cultures (DSMZ). 2024. Available from: www.Bacterio.net. Retrieved 28 Oct 2024."},{"key":"e_1_3_2_5_2","first-page":"905","volume-title":"Manual of Clinical Microbiology","author":"Edelstein PH","year":"2019","unstructured":"Edelstein PH. 2019. Legionellap 905\u2013920. In Carroll KC, Pfaller MA, Landry ML, McAdam AJ, Patel R, Richter SS, Warnock DW (ed), Manual of Clinical Microbiology, 12th. ASM press, Washington DC.","edition":"12"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.0380-15"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01066-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.039248-0"},{"key":"e_1_3_2_9_2","first-page":"635","volume-title":"Basic and Clinical Pharmacology","author":"Goldfien A","year":"1998","unstructured":"Goldfien A. 1998. Adrenocorticosteroids and adrenocortical antagonistsp 635\u2013652. In Katzung BG (ed), Basic and Clinical Pharmacology, 7th. Appleton and Lange, Stamford, Connecticut.","edition":"7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1309\/HN44-XQYM-JMAQ-2EDL"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03416-14"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/498248"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007552"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01776-19"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250364"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068244"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01670-06"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0461"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.22.3.422-424.1985"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2803.211435"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00043-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00043-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T17:28:28Z","timestamp":1757438908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00043-24"}},"subtitle":[],"editor":[{"given":"Ritu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,7]]}},"alternative-id":["10.1128\/asmcr.00043-24"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00043-24","relation":{},"ISSN":["2996-2684"],"issn-type":[{"type":"electronic","value":"2996-2684"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"article-number":"e00043-24"}}