{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:22:28Z","timestamp":1788268948832,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>Measles vaccination is recommended for hematopoietic stem cell transplant (HSCT) recipients \u226524 months post-transplant in the absence of graft-versus-host disease and immunosuppressive therapy. Administration of live vaccines during immunosuppression may result in iatrogenic injury.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>We describe a 76-year-old patient with stage 3 multiple myeloma who had undergone autologous HSCT and received multiple therapies, including chimeric antigen receptor T-cell therapy and recent daratumumab treatment. Approximately 1 month after measles, mumps, and rubella (MMR) vaccination, she presented with progressive respiratory symptoms and hypoxia. Despite broad-spectrum antimicrobials and supportive care, her condition deteriorated, requiring ICU admission and mechanical ventilation. Molecular testing of her bronchoalveolar fluid detected the measles virus vaccine strain and seasonal coronavirus OC63. The patient succumbed to her illness on hospital day 16.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>This case highlights the rare but severe complication of measles vaccine-associated pneumonia in an immunocompromised host. While guidelines support MMR vaccination \u226524 months post-HSCT, ongoing immunosuppression may increase susceptibility to vaccine-related adverse events. Rising measles incidence in North America underscores the need for individualized vaccination strategies, balancing infection risk and vaccine safety. Healthcare providers should exercise caution when considering live-attenuated vaccines in HSCT recipients with recent immunosuppressive therapy. Further research is needed to refine vaccination guidelines for this vulnerable population.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00050-26","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:02:20Z","timestamp":1779368540000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Co-detection of measles virus vaccine strain and seasonal coronavirus in an immunocompromised patient with pneumonia"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4366-6166","authenticated-orcid":true,"given":"C.","family":"Anderson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00c2tyx86","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, University of Utah","place":["Salt Lake City, USA"]},{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"ARUP Laboratories","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Odrobina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Medicine, University of Utah","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. T.","family":"Murugan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Medicine, University of Utah","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-9314","authenticated-orcid":false,"given":"B. 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Measles cases and outbreaks"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit684"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30600-5"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab326"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01402-25"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003865"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix160"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0386-z"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2024.105696"},{"key":"e_1_3_1_12_2","first-page":"603","article-title":"Measles pneumonitis following measles-mumps-rubella vaccination of a patient with HIV infection, 1993","volume":"45","author":"Centers for Disease Control and Prevention (CDC)","year":"1996","unstructured":"Centers for Disease Control and Prevention (CDC). 1996. Measles pneumonitis following measles-mumps-rubella vaccination of a patient with HIV infection, 1993. MMWR Morb Mortal Wkly Rep 45:603\u2013606.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_1_13_2","unstructured":"2025. PAHO calls for regional action as the Americas lose measles elimination status. Available from: https:\/\/www.paho.org\/en\/news\/10-11-2025-paho-calls-regional-action-americas-lose-measles-elimination-status"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1905181"},{"key":"e_1_3_1_15_2","first-page":"427","article-title":"Immunity to and immunization against measles, rubella and mumps in patients after autologous bone marrow transplantation","volume":"9","author":"Pauksen K","year":"1992","unstructured":"Pauksen K, Duraj V, Ljungman P, Sj\u00f6lin J, Oberg G, L\u00f6nnerholm G, Fridell E, Smedmyr B, Simonsson B. 1992. Immunity to and immunization against measles, rubella and mumps in patients after autologous bone marrow transplantation. Bone Marrow Transplant 9:427\u2013432.","journal-title":"Bone Marrow Transplant"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.657.657"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab504"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-550475"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(06)80114-9"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac574"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V130.Suppl_1.3148.3148"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-408"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00050-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00050-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:00:34Z","timestamp":1788267634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00050-26"}},"subtitle":[],"editor":[{"given":"Nicholas M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1128\/asmcr.00050-26"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00050-26","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00050-26"}}