{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:14:17Z","timestamp":1785417257385,"version":"3.56.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n \n Peritoneal dialysis-associated peritonitis caused by\n Mycobacterium abscessus<\/jats:italic>\n is a rare and difficult-to-treat infection that frequently results in peritoneal dialysis failure. Since\n M. abscessus<\/jats:italic>\n is intrinsically resistant to many antibiotics, therapeutic decisions are challenging. While data are limited, a prolonged course of antibiotics with at least two or three agents is recommended, guided by susceptibility testing. Many regimens use amikacin, which can worsen renal function and cause deafness. There is limited safety and efficacy data on newer antimycobacterial medications in children. Safe and well-tolerated options are needed for the treatment of infections caused by\n M. abscessus<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n Herein, we present the case of a toddler with dysplastic congenital renal disease, who developed peritoneal dialysis catheter-related\n M. abscessus<\/jats:italic>\n peritonitis and was treated with a multidrug regimen including two \u03b2-lactam antibiotics. This resulted in clinical and microbiologic cure, despite peritoneal failure and transition to hemodialysis. Based on predicted synergy testing, the patient was treated with a combination that included meropenem and ceftaroline for the initial intensified intravenous phase, followed by a regimen that included amoxicillin combined with cefdinir for step-down therapy. This allowed the option of enteral therapy and limited the use of more toxic medications or agents with inadequate information for use in children.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This case highlights the potential benefit of dual \u03b2-lactam therapy for the treatment of\n M. abscessus<\/jats:italic>\n infection as a well-tolerated regimen for a difficult-to-treat infection. To our knowledge, this is the first report using this approach for the treatment of\n M. abscessus<\/jats:italic>\n peritonitis.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00056-25","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:52:36Z","timestamp":1752670356000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Case report of peritoneal dialysis-associated peritonitis caused by\n Mycobacterium abscessus<\/i>\n in a child, successfully treated with dual \u03b2-lactam combination therapy"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1718-0901","authenticated-orcid":true,"given":"Debbie-Ann","family":"Shirley","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Pediatrics, University of Florida College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Maurtua-Neumann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Pediatrics, University of Florida College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Shoemaker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Nephrology, Department of Pediatrics, University of Florida College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"DeSear","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kvbr153","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, University of Florida Health Shands Hospital","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid M.","family":"Dousa","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221080586"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608241274096"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-023-00457-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03547.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00535-2020"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201304-085OC"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01206-17"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","unstructured":"le Run E Tettelin H Holland SM Zelazny AM. 2024. Evolution towards extremely high \u03b2-lactam resistance in Mycobacterium abscessus outbreak strains. bioRxiv:2024.05.08.593223. doi:10.1101\/2024.05.08.593223","DOI":"10.1101\/2024.05.08.593223"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-019-0302-1"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01050-15"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab535"},{"key":"e_1_3_1_13_2","volume-title":"Performance standards for susceptibility testing of Mycobacteria, Nocardia spp., and other aerobic actinomycetes","author":"Anonymous","year":"2023","unstructured":"Anonymous. 2023. Performance standards for susceptibility testing of Mycobacteria, Nocardia spp., and other aerobic actinomycetes. 2nd Edition. CLSI supplement M24S. Clinical and Laboratory Standards Institute.","edition":"2"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0331-1"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00319-24"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad312"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.035"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40993"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02273"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00098-20"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03529-21"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02895-18"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku111"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57844-8"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210927"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.997-1001.2003"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000202210.22512.88"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00056-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00056-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T17:29:44Z","timestamp":1757438984000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00056-25"}},"subtitle":[],"editor":[{"given":"Ritu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9,2]]}},"alternative-id":["10.1128\/asmcr.00056-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00056-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00056-25"}}