{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:20Z","timestamp":1785434780820,"version":"3.56.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Trichophyton indotineae<\/jats:italic>\n                        is an emerging\n                        <jats:italic toggle=\"yes\">Trichophyton<\/jats:italic>\n                        species associated with extensive dermatophytosis frequently demonstrating terbinafine resistance. While early cases were reported in South Asia,\n                        <jats:italic toggle=\"yes\">T. indotineae<\/jats:italic>\n                        has since spread globally, with several cases reported in the United States since 2023. To our knowledge, we describe the first cases reported in Virginia.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        Patients A and B each presented to the dermatology clinic with a diffuse, pruritic rash unresponsive to previous courses of topical and antifungal therapy. Both presentations raised concern for\n                        <jats:italic toggle=\"yes\">T. indotineae<\/jats:italic>\n                        infection, which was confirmed with internal transcribed spacer (ITS) genome sequencing of isolates from the lesions. Both patients were initially prescribed an 8-week course of itraconazole 200 mg daily. Patient A required an additional month of treatment, but both patients had improved at follow-up.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        The present cases highlight several key points regarding the epidemiology, diagnosis, and management of\n                        <jats:italic toggle=\"yes\">T. indotineae<\/jats:italic>\n                        infections, including continued expansion within the US, the need for ITS sequencing to distinguish\n                        <jats:italic toggle=\"yes\">T. indotineae<\/jats:italic>\n                        from\n                        <jats:italic toggle=\"yes\">Trichophyton mentagrophytes<\/jats:italic>\n                        and\n                        <jats:italic toggle=\"yes\">Trichophyton interdigitale<\/jats:italic>\n                        , and the growing role of oral itraconazole as first-line therapy.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00058-25","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:03:46Z","timestamp":1772201026000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["<i>Trichophyton indotineae<\/i>\n                    in Virginia: diagnostic identification and case report"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0335-4739","authenticated-orcid":true,"given":"Hope","family":"Winfield","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0153tk833","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Virginia School of Medicine","place":["Charlottesville, 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USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3004.240115"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7219a4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010795"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00562-23"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8070757"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.1126"},{"key":"e_1_3_2_8_2","volume-title":"MM18\u2014interpretive criteria for identification of bacteria and fungi by targeted DNA sequencing; approved guideline","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2018","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2018. MM18\u2014interpretive criteria for identification of bacteria and fungi by targeted DNA sequencing; approved guideline. 2nd ed. CLSI.","edition":"2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01407-24"},{"key":"e_1_3_2_10_2","unstructured":"American Academy of Dermatology Association. 2025. Preventing and treating Trichophyton indotineae. American Academy of Dermatology Association. Available from: https:\/\/www.aad.org\/member\/clinical-quality\/clinical-care\/emerging-diseases\/dermatophytes\/preventing-treating-trichophyton-indotineae"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7110983"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-024-00835-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8101103"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13091"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00059-22"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00058-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00058-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:00:58Z","timestamp":1777986058000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00058-25"}},"subtitle":[],"editor":[{"given":"Carey-Ann D.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1128\/asmcr.00058-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00058-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00058-25"}}