{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:56Z","timestamp":1790717156771,"version":"4.1.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n Cyclosporiasis is a rare cause of chronic diarrhea and malabsorption in immunosuppressed patients.<\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n We report an unusual case of chronic\n Cyclospora<\/jats:italic>\n infection in a heart transplant patient with a five-month history of watery diarrhea and weight loss. Initial stool testing failed to discover a causative pathogen. Duodenal biopsy showed histologic findings of intraepithelial lymphocytosis and partial villous blunting, raising the possibility of celiac disease. A repeat duodenal biopsy five months later revealed intracellular parasites with gametocyte, meront, and schizont forms, and the diagnosis of\n Cyclospora<\/jats:italic>\n infection was confirmed by BIOFIRE Gastrointestinal (GI) Pathogen Panel.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Morphologic diagnosis of enteric parasite infections is challenging and requires a high level of clinical suspicion in immunosuppressed patients. In addition to significant exposures and travel history, chronic immunosuppression should prompt extensive microbial testing, including stool ova and parasite, acid-fast testing, and\/or multiplex PCR for GI pathogens in post-transplant patients with unexplained diarrhea.<\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00062-25","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:37:34Z","timestamp":1754656654000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Chronic\n Cyclospora<\/i>\n infection in a heart transplant patient with intestinal malabsorption: a case report"],"prefix":"10.1128","volume":"1","author":[{"given":"Katie","family":"Ambrose","sequence":"first","affiliation":[{"name":"University of Oklahoma School of Community Medicine","place":["Tulsa, USA"]},{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-7214","authenticated-orcid":false,"given":"Robert","family":"Hamilton-Seth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie","family":"Jackson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Gastroenterology, Hepatology and Motility, University of Kansas Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sigler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001tmjg57","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, University of Kansas Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daffolyn Rachael","family":"Fels Elliott","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036c9yv20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7090317"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091863"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab495"},{"key":"e_1_3_1_5_2","first-page":"613","article-title":"Co-infection with Cryptosporidium parvum and cyclospora cayetanensis in immunocompromised patients","volume":"36","author":"Helmy MMF","year":"2006","unstructured":"Helmy MMF, Rashed LA, Abdel-Fattah HS. 2006. Co-infection with Cryptosporidium parvum and cyclospora cayetanensis in immunocompromised patients. J Egypt Soc Parasitol 36:613\u2013627.","journal-title":"J Egypt Soc Parasitol"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-1026-8"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2022.03.004"},{"key":"e_1_3_1_8_2","volume-title":"Manual of Clinical Microbiology","author":"Qvarnstrom Y","year":"2023","unstructured":"Qvarnstrom Y, Arrowood M. 2023 Cystoisospora, Cyclospora, and Sarcocystis. In Carroll Karen C, Pfaller Michael A (ed), Manual of Clinical Microbiology. Vol. 13. American Society for Microbiology;2023, ed."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100217"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13618"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028x-67.5.1044"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2018.06.009"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00043"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2020.716-725"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118202200172X"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00062-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00062-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:01:09Z","timestamp":1762261269000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00062-25"}},"subtitle":[],"editor":[{"given":"Nicholas M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11,4]]}},"alternative-id":["10.1128\/asmcr.00062-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00062-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00062-25"}}