{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:29:28Z","timestamp":1787016568984,"version":"build-2736575974"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Mycobacterium abscessus<\/jats:italic>\n                        (\n                        <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                        ) infections are poorly responsive to antibiotics, with lower rates of clinical and microbiological clearance for macrolide-resistant isolates compared to macrolide-susceptible strains. Successful treatment of macrolide-resistant\n                        <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                        infection has not been reported for children.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        Here we report two children with macrolide-resistant\n                        <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                        infections who achieved clinical remission and microbiologic clearance using multi-drug treatment regimens including clofazimine, bedaquiline, linezolid or eravacycline, dual \u03b2-lactam therapy with meropenem and amoxicillin, and, in one case, phage therapy.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        Successful treatment of macrolide-resistant\n                        <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                        infections in children can be achieved using multi-drug regimens including novel dual \u03b2-lactam combinations and phage therapy. Dose adjustment with therapeutic drug monitoring can ameliorate some drug-induced toxicities in children.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00087-24","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T09:02:11Z","timestamp":1749718931000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of macrolide-resistant\n                    <i>Mycobacterium abscessus<\/i>\n                    infection using multi-drug regimens including dual \u03b2-lactams and phage therapy: case reports in two 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