{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:09Z","timestamp":1790934369941,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n \n Lomentospora prolificans<\/jats:italic>\n is an opportunistic fungal\n pathogen associated with significant morbidity and mortality in\n immunocompromised individuals. Its intrinsic resistance to most\n antifungal agents poses challenges in clinical management, particularly\n in patients with hematological malignancies.\n <\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n Herein, we report the case of a 60-year-old male with recently diagnosed\n acute monocytic leukemia who developed a disseminated\n L.\n prolificans<\/jats:italic>\n infection during induction chemotherapy.\n Despite standard prophylactic antimicrobials, the patient experienced\n febrile neutropenia, progressive pulmonary findings, and neurological\n complications, culminating in disseminated fungal infection. Blood\n cultures confirmed the diagnosis, and antifungal therapy was promptly\n expanded. However, the infection progressed rapidly, and the patient\n died despite aggressive therapeutic interventions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This case highlights the complexities of diagnosing and treating\n L. prolificans<\/jats:italic>\n infections in profoundly\n immunosuppressed patients. It underscores the importance of heightened\n clinical suspicion, early recognition, aggressive management, and the\n need for continued development of novel antifungal agents and diagnostic\n techniques.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00093-25","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:08:25Z","timestamp":1758805705000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Disseminated\n Lomentospora prolificans<\/i>\n infection in a neutropenic patient with acute monocytic leukemia: a clinical and diagnostic challenge"],"prefix":"10.1128","volume":"1","author":[{"given":"Sierra","family":"Amaya","sequence":"first","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-0535","authenticated-orcid":false,"given":"Giancarlo","family":"Giovannini-Sanguineti","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn D.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0573-4957","authenticated-orcid":true,"given":"Stefan","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, 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