{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:45:01Z","timestamp":1790613901641,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The National Institute of Biological Resources of the Ministry of Environment, Korea","award":["2024-0153-01"],"award-info":[{"award-number":["2024-0153-01"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Talaromyces<\/jats:italic>\n                        , a genus phylogenetically related to\n                        <jats:italic toggle=\"yes\">Penicillium<\/jats:italic>\n                        , is saprophytic except for\n                        <jats:italic toggle=\"yes\">Talaromyces marneffei<\/jats:italic>\n                        . Herein, we describe the first documented case of fungemia caused by\n                        <jats:italic toggle=\"yes\">Talaromyces tumuli<\/jats:italic>\n                        .\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        A case without overt predisposing conditions had suffered from recurrent bacteremia of various causes over the past 3 years and was admitted due to prolonged fever despite antimicrobial therapy this time. Three sets of blood cultures were negative at admission. On hospitalization day (HD) 5, two sets of blood cultures obtained via a subclavian venous catheter (SVC) became positive for hyphae in aerobic vials only with detection time of 67 h, respectively. Subculture of positive blood culture vial to Sabouraud dextrose agar yielded blue-green colonies without production of red pigments. Microscopic examination showed biverticillate\n                        <jats:italic toggle=\"yes\">Penicillium<\/jats:italic>\n                        -like conidiophores and species identification using the MALDI Biotyper sirius System (Bruker) resulted in a first-rank match to\n                        <jats:italic toggle=\"yes\">Talaromyces funiculosus<\/jats:italic>\n                        with non-reliable identification score of 1.63. Sequencing of the regions of\n                        <jats:italic toggle=\"yes\">ITS, BenA, CaM<\/jats:italic>\n                        , and\n                        <jats:italic toggle=\"yes\">RPB2<\/jats:italic>\n                        genes identified it as\n                        <jats:italic toggle=\"yes\">T. tumuli<\/jats:italic>\n                        . Subsequent blood cultures remained positive for it on six episodes until removal of the SVC on HD 18, despite voriconazole treatment.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        This case was the first case of a central venous catheter-associated bloodstream infection caused by\n                        <jats:italic toggle=\"yes\">T. tumuli<\/jats:italic>\n                        .\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00096-25","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:04:46Z","timestamp":1760533486000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Unusual fungemia caused by non-\n                    <i>marneffei Talaromyces<\/i>\n                    in an immunocompetent host"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-4257","authenticated-orcid":true,"given":"Eun Jeong","family":"Won","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-251X","authenticated-orcid":true,"given":"Jina","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, South 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