{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:11Z","timestamp":1785412511876,"version":"3.56.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"French National Reference Center for Antimicrobial Resistance"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Corynebacterium striatum<\/jats:italic>\n                        , a commensal of the skin microbiota, can cause invasive osteoarticular infections that are challenging to diagnose and treat due to biofilm formation. Daptomycin, owing to its potent activity against gram-positive bacteria and favorable toxicity profile, is frequently used as empirical therapy in the management of postoperative bone and joint infections. However, cases of acquired resistance remain rare and poorly understood.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        We describe a case of chronic T11\u2013T12 spondylodiscitis in a paraplegic patient. During the first surgical intervention, a daptomycin-susceptible\n                        <jats:italic toggle=\"yes\">C. striatum<\/jats:italic>\n                        isolate (CORY-1) was recovered. The patient received 14 days of daptomycin monotherapy (10 mg\/kg). At the time of the second surgery, a daptomycin-resistant\n                        <jats:italic toggle=\"yes\">C. striatum<\/jats:italic>\n                        strain (CORY-2) was isolated. Whole-genome sequencing revealed only 13 single nucleotide polymorphisms between the two isolates, including a nonsense mutation in\n                        <jats:italic toggle=\"yes\">pgsA<\/jats:italic>\n                        , likely responsible for resistance. Additional mutations in\n                        <jats:italic toggle=\"yes\">mltG<\/jats:italic>\n                        and\n                        <jats:italic toggle=\"yes\">ftsI<\/jats:italic>\n                        genes may contribute to the modest increases observed in \u03b2-lactam minimum inhibitory concentrations.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        This case highlights the risk of rapid daptomycin resistance emergence in\n                        <jats:italic toggle=\"yes\">C. striatum<\/jats:italic>\n                        under selective pressure. Daptomycin should be used with caution for long-term infections caused by this species. Alternative agents such as vancomycin or oxazolidinones may offer more reliable therapeutic options.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00106-25","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:00:27Z","timestamp":1757595627000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Rapid acquisition of daptomycin resistance in a\n                    <i>Corynebacterium striatum<\/i>\n                    osteoarticular infection: case report and discussion on antimicrobial resistance"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9484-7932","authenticated-orcid":true,"given":"Ines","family":"Rezzoug","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pg5jh14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bacteriology-Hygiene, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris","place":["Le Kremlin-Bic\u00eatre, France"]},{"name":"Team 'Resist' UMR1184 'Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB)', Faculty of Medicine, INSERM, Paris-Saclay University","place":["Le Kremlin-Bic\u00eatre, France"]},{"id":[{"id":"https:\/\/ror.org\/05c9p1x46","id-type":"ROR","asserted-by":"publisher"}],"name":"Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacterales","place":["Le Kremlin-Bic\u00eatre, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Zamparini","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046bx1082","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Bic\u00eatre University Hospital, APHP","place":["Le Kremlin-Bic\u00eatre, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Court","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pg5jh14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Orthopedic Surgery, Bic\u00eatre Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris","place":["Le Kremlin-Bic\u00eatre, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Saint-Joseph & Marie-Lannelongue Hospitals","place":["Paris, France"]},{"id":[{"id":"https:\/\/ror.org\/02b6c0m75","id-type":"ROR","asserted-by":"publisher"}],"name":"Micalis Institute UMR 1319, Universit\u00e9 Paris-Saclay, INRAe, AgroParisTech","place":["Ch\u00e2tenay-Malabry, 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