{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:13:42Z","timestamp":1785417222001,"version":"3.56.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>\n                        <jats:bold>Background<\/jats:bold>\n                      <\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Mycoplasma pneumoniae<\/jats:italic>\n                        is a common cause of\n                            community-acquired pneumonia among children and young adults.\n                            Surveillance within the United States has identified increased levels of\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        -mediated respiratory disease\n                            following a multi-year period of minimal detection during the COVID-19\n                            pandemic. A wide spectrum of extrapulmonary complications can be\n                            associated with\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        infections, including\n                            dermatological disease. Reactive infectious mucocutaneous eruption\n                            (RIME) is a constellation of immune-mediated extrapulmonary\n                            manifestations causing ulceration of multiple mucous membranes that\n                            occurs in up to 25%\n                        <jats:italic toggle=\"yes\">M<\/jats:italic>\n                        .\n                        <jats:italic toggle=\"yes\">pneumoniae<\/jats:italic>\n                        cases.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        An adolescent patient presenting with acute hypoxic respiratory failure\n                            and an eight-day history of conjunctivitis and oral ulcers tested\n                            positive for\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        from a nasopharyngeal\n                            specimen and was diagnosed with RIME. A retrospective review of\n                            increased\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        test positivity and\n                            hospitalizations at our institution was undertaken, which mirrored\n                            national trends.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        As dedicated\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        testing may not be available\n                            in all settings, clinicians should consider a diagnosis of RIME for\n                            patients presenting with similar para- or post-infectious mucositis,\n                            even in the absence of traditional respiratory symptoms. RIME incidence\n                            is expected to increase in the setting of a higher prevalence of\n                        <jats:italic toggle=\"yes\">M. pneumoniae<\/jats:italic>\n                        disease. As RIME can be associated\n                            with significant morbidity including dehydration and weight loss as well\n                            as disease recurrence, proper management of patient symptomatology is\n                            essential.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00107-25","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T13:01:11Z","timestamp":1757682071000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Reactive infectious mucocutaneous eruption: an increasingly                    encountered complication during periods of increased\n                    <i>Mycoplasma                        pneumoniae<\/i>\n                    transmission\u2014a case 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