{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:32:00Z","timestamp":1775100720662,"version":"3.50.1"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM113896, T32GM145432"],"award-info":[{"award-number":["T32GM113896, T32GM145432"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG044271"],"award-info":[{"award-number":["P30AG044271"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004538, T32TR004544, T32TR004545"],"award-info":[{"award-number":["UM1TR004538, T32TR004544, T32TR004545"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:sec>\n              <jats:title>Background<\/jats:title>\n              <jats:p>\n                Deep-seated\n                <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                infections are difficult to treat and require appropriate antibiotic regimens for clinical success. Recent studies have shown that continuous infusion (CI) of \u03b2-lactam antibiotics is associated with reduced mortality, though optimal dosages remain to be determined. Here, we present a case in which high-dose cefazolin, at 10 g daily CI, was used to safely and successfully clear methicillin-susceptible\n                <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                (MSSA) pneumonia.\n              <\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n              <jats:title>Case Summary<\/jats:title>\n              <jats:p>A 33-year-old male was admitted to the medical intensive care unit with suspected MSSA community-acquired pneumonia. Over the course of a 43-day hospital stay, the patient\u2019s pneumonia relapsed twice following two 5- to 7-day courses of cefazolin 8 g daily CI. Clearance of the pneumonia was achieved after a 14-day course of cefazolin 10 g daily CI, and the patient was discharged.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>Here, we describe a patient with incomplete clearance of MSSA pneumonia despite two 5- to 7-day courses of cefazolin 8 g daily CI. Following a 14-day course of cefazolin 10 g daily CI, the patient\u2019s fever and leukocytosis rapidly resolved without direct evidence of drug-related toxicity. This case report provides evidence for the safe and effective use of high-dose cefazolin CI in the clearance of persistent MSSA pneumonia.<\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/asmcr.00114-24","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T08:19:42Z","timestamp":1743409182000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Successful clearance of persistent\n            <i>Staphylococcus aureus<\/i>\n            pneumonia with high-dose continuous infusion cefazolin"],"prefix":"10.1128","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9586-6228","authenticated-orcid":true,"given":"Annie A.","family":"Smelter","sequence":"first","affiliation":[{"name":"Joe R. and Teresa Lozano Long School of Medicine, The University of Texas Health at San Antonio","place":["San Antonio, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-4787","authenticated-orcid":true,"given":"Christopher R.","family":"Frei","sequence":"additional","affiliation":[{"name":"Joe R. and Teresa Lozano Long School of Medicine, The University of Texas Health at San Antonio","place":["San Antonio, USA"]},{"name":"College of Pharmacy, The University of Texas at Austin","place":["Austin, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9181-0786","authenticated-orcid":true,"given":"Dan F.","family":"Smelter","sequence":"additional","affiliation":[{"name":"Joe R. and Teresa Lozano Long School of Medicine, The University of Texas Health at San Antonio","place":["San Antonio, USA"]},{"name":"College of Pharmacy, The University of Texas at Austin","place":["Austin, 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