{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:07:43Z","timestamp":1785424063609,"version":"3.56.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["ARIES PROJECT 2021\/10599-3"],"award-info":[{"award-number":["ARIES PROJECT 2021\/10599-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["383955\/2024-6"],"award-info":[{"award-number":["383955\/2024-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        We report the first case of invasive human infection caused by\n                        <jats:italic toggle=\"yes\">Candida berthetii<\/jats:italic>\n                        in a preterm infant.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        A premature neonate who required prolonged hospitalization, intensive care support, multiple surgical interventions, and broad-spectrum antibiotics developed persistent candidemia due to\n                        <jats:italic toggle=\"yes\">C. berthetii<\/jats:italic>\n                        . Species identification was confirmed through sequencing of the internal transcribed spacer region of ribosomal DNA. Antifungal susceptibility testing, performed using the the European Committee on Antimicrobial Susceptibility Testing (EUCAST) microbroth dilution method, revealed high minimal inhibitory concentrations (MICs) to fluconazole and anidulafungin but low MICs for amphotericin B. Despite switching to liposomal amphotericin B, the infant progressed to multiple organ dysfunction and died. The poor clinical outcome was attributed to both the severity of underlying conditions associated with candidemia and the delay in starting adequate antifungal therapy.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        This case broadens the current understanding of rare yeast pathogens and highlights the critical need for improved diagnostic tools to accurately detect and identify uncommon\n                        <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                        species. Clinicians should remain vigilant to the emergence of rare yeast pathogens causing fungemia, especially among immunosuppressed hosts undergoing invasive medical procedures and prolonged exposure to broad-spectrum antimicrobials.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00120-25","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:44:42Z","timestamp":1764078282000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["First case of a human\n                    <i>Candida berthetii<\/i>\n                    systemic infection in a preterm infant: a case report"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-1332","authenticated-orcid":true,"given":"Elaine Cristina","family":"Francisco","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Escola Paulista de Medicina-Universidade Federal de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]},{"id":[{"id":"https:\/\/ror.org\/05syd6y78","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Monitoring Antimicrobial Resistance Patterns and Genetic Diversity in Clinical and Environmental Isolates from Brazilian Biomes, Universidade Federal do Paran\u00e1","place":["Curitiba, Brazil"]},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES)","place":["S\u00e3o Paulo, Brazil."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6184-9060","authenticated-orcid":true,"given":"Fatima M. V.","family":"Porfirio","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Sepaco","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-9230","authenticated-orcid":true,"given":"Larissa M.","family":"Favarello","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Escola Paulista de Medicina-Universidade Federal de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3843-5770","authenticated-orcid":true,"given":"Elisa J. 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