{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:59:18Z","timestamp":1785419958493,"version":"3.56.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        Septic arthritis of native joints remains an uncommon but serious clinical condition affecting approximately two per 100,000 individuals annually. The synovial membrane, being highly vascular and lacking a protective basement membrane, is particularly susceptible to hematogenous bacterial seeding, especially in patients with pre-existing joint disease.\n                        <jats:italic toggle=\"yes\">Corynebacterium propinquum<\/jats:italic>\n                        , typically regarded as a respiratory commensal, has rarely been implicated in deep-seated infections.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        We report the first known case of\n                        <jats:italic toggle=\"yes\">C. propinquum<\/jats:italic>\n                        isolated from synovial fluid in a patient with native knee septic arthritis. The 59-year-old female had a history of bilateral knee osteoarthritis and recent intra-articular corticosteroid injections. Initial synovial fluid cultures were negative; however, enrichment using aerobic blood culture bottles, followed by subculture, yielded\n                        <jats:italic toggle=\"yes\">C. propinquum<\/jats:italic>\n                        identified by MALDI-TOF MS. The organism grew on aerobic blood agar but not on anaerobic media or thioglycolate broth. The patient was successfully treated with intravenous daptomycin, followed by ceftriaxone, with subsequent clinical improvement.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        This case highlights the diagnostic value of using enrichment culture and comprehensive laboratory-clinical correlation to recognize clinically significant, low-virulence organisms, such as\n                        <jats:italic toggle=\"yes\">Corynebacterium propinquum<\/jats:italic>\n                        . Accurate species-level identification and thoughtful interpretation within the clinical context are essential to distinguish contamination from true infection, particularly in sterile-site cultures associated with native joint infections.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00138-25","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:00:11Z","timestamp":1769004011000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Septic arthritis due to\n                    <i>Corynebacterium propinquum<\/i>\n                    : first report of isolation from synovial fluid in a native joint"],"prefix":"10.1128","volume":"2","author":[{"given":"Rudolf","family":"Kotula","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g635h87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Methodist Hospital","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kotula","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058w59113","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Immunology & Pathology, Des Moines University","place":["West Des Moines, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8860-2457","authenticated-orcid":true,"given":"Nagarjuna Reddy","family":"Cheemarla","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g635h87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Methodist Hospital","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1391789"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.78.277"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.14740\/jmc2795w"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2023.03.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2013.10.013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-025-04159-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1556\/030.2025.02532"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01552-24"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.125"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00796-12"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-021-02246-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2013010\u20131254\u20133"},{"key":"e_1_3_3_14_2","unstructured":"Klement MR Goswami K Nelson C Travers C. 2019. 2018 International Consensus Meeting (ICM) on musculoskeletal infection - question 13. https:\/\/www.ors.org\/wp-content\/uploads\/2019\/01\/Question-13.pdf."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.12.4468-4471.2001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01199-24"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2211.160141"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00138-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00138-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:01:47Z","timestamp":1772546507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00138-25"}},"subtitle":[],"editor":[{"given":"Nicholas M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,3]]}},"alternative-id":["10.1128\/asmcr.00138-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00138-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00138-25"}}