{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:55:16Z","timestamp":1785426916018,"version":"3.56.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Background<\/jats:title>\n \n Ureaplasma<\/jats:italic>\n spp. are a rare cause of invasive disease outside of the neonatal period. Recent studies have shown that immunosuppression with B-cell depleting therapies, such as rituximab or obinutuzumab, can increase the risk of invasive infection. We present a case in which a patient receiving B-cell depleting therapy for anti-neutrophil cytoplasmic antibody-associated vasculitis and pauci-immune nephritis was diagnosed with disseminated, invasive\n Ureaplasma<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Case Summary<\/jats:title>\n \n A 17-year-old female with documented B-cell depletion presented to the emergency department from the pediatric infectious disease clinic with persistent shoulder pain. Within the first month of admission, the patient developed multifocal abscesses with joint involvement and an echodensity resembling a possible vegetation, all of which were unresponsive to broad-spectrum antibiotics. A broad-spectrum polymerase chain reaction test detected\n Ureaplasma urealyticum<\/jats:italic>\n in aspirated joint fluid from multiple anatomic sites. Clinical improvement occurred after initiation of combination therapy with intravenous doxycycline and levofloxacin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We describe a patient with documented iatrogenic B cell depletion presenting with a disseminated, multifocal invasive\n Ureaplasma<\/jats:italic>\n infection including osteoarthritis, cellulitis, and soft tissue abscess. Following a 6-week course of levofloxacin, the patient\u2019s C-reactive protein, fever, and pain resolved without further evidence of disease. This case report highlights the importance of considering disseminated, invasive\n Ureaplasma<\/jats:italic>\n spp. when evaluating B-cell depleted patients with challenging multifocal symptom complexes. In addition, this case report highlights the critical role of molecular diagnosis in identifying this fastidious pathogen.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/asmcr.00164-25","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:00:15Z","timestamp":1770904815000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Invasive\n Ureaplasma<\/i>\n infection in a pediatric patient: a case report"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0842-8999","authenticated-orcid":true,"given":"Brice","family":"Laney","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Monroe Carell Junior Children\u2019s Hospital at Vanderbilt","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Dulek","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-5635","authenticated-orcid":true,"given":"David C.","family":"Gaston","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2848-4532","authenticated-orcid":true,"given":"Natalya","family":"Beneschott","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-6861","authenticated-orcid":true,"given":"Sophie E.","family":"Katz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Gillon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Monroe Carell Junior Children\u2019s Hospital at Vanderbilt","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-2222","authenticated-orcid":true,"given":"Stephanie","family":"Rolsma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center","place":["Nashville, USA"]},{"id":[{"id":"https:\/\/ror.org\/05dq2gs74","id-type":"ROR","asserted-by":"publisher"}],"name":"Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases","author":"Kimberlin DW","year":"2024","unstructured":"Kimberlin DW, Banerjee R, Barnett E, Lynfield R, Sawyer MH. 2024. Ureaplasma urealyticum and Ureaplasma parvum infections. In Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases. American Academy of Pediatrics."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-257261"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz399"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-4453(98)80174-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.3.183"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01877-09"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13032"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14538"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-237916"},{"key":"e_1_3_2_11_2","first-page":"1","volume-title":"Manual of Clinical Microbiology","author":"Waites KB","year":"2023","unstructured":"Waites KB, B\u00e9b\u00e9ar C. 2023. Mycoplasma and Ureaplasma, p 1\u201323. In CarrollKC, Pfaller MA (ed), Manual of Clinical Microbiology, 13th ed. 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