{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:22:29Z","timestamp":1788268949337,"version":"build-2803163510"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        Intravesical Bacille Calmette-Guerin (BCG) therapy with live-attenuated form of\n                        <jats:italic toggle=\"yes\">Mycobacterium bovis<\/jats:italic>\n                        (\n                        <jats:italic toggle=\"yes\">M. bovis<\/jats:italic>\n                        ) is used as a treatment of early-stage bladder cancers. Documented adverse reactions are usually local and time limited, with severe central nervous system (CNS) complications being exceedingly rare. We report an 88-year-old patient with papillary urothelial carcinoma who presented with recurring neurological complications for over a year after treatment with intravesical BCG therapy.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        MRI at initial presentation revealed a dural-based left frontoparietal mass. Histological examination of the resected tissue revealed granulation tissue, necrosis, and lymphohistiocytic inflammation. Stains for organisms and cultures were negative, as was broad-range PCR. Two additional CNS resections performed followed detection of new lesions on follow-up. A mycobacterial culture from abscess fluid from the last resection recovered\n                        <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                        complex that, on region of detection signature pattern analysis, was identified as\n                        <jats:italic toggle=\"yes\">M. bovis<\/jats:italic>\n                        BCG.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        This case represents one of the rare documented reports of an\n                        <jats:italic toggle=\"yes\">M. bovis<\/jats:italic>\n                        BCG CNS infection resulting from intravesical BCG treatment. BCG infection should be considered in the differential of CNS infections in patients with a history of BCG treatment so early life-saving therapy can be instituted.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00186-25","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:00:16Z","timestamp":1784293216000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["<i>Mycobacterium bovis<\/i>\n                    BCG infection of the brain following intravesical BCG treatment"],"prefix":"10.1128","volume":"2","author":[{"given":"Sierra","family":"Amaya","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04drvxt59","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven N.","family":"Schwartz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04drvxt59","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-4500","authenticated-orcid":true,"given":"James E.","family":"Kirby","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04drvxt59","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-3793","authenticated-orcid":true,"given":"Hemant","family":"Varma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04drvxt59","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.122"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/869286"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00194-23"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190016636533"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2019.1647714"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i7.301"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/572410"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17446"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlad029"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.4.393"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.10.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu147"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00186-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00186-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:00:35Z","timestamp":1788267635000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00186-25"}},"subtitle":[],"editor":[{"given":"Carey-Ann D.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1128\/asmcr.00186-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00186-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00186-25"}}