{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:11:20Z","timestamp":1785413480460,"version":"3.56.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100006458","name":"Children's Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:sec>\n                      <jats:title>Background<\/jats:title>\n                      <jats:p>\n                        Recurrent neonatal infection caused by the same bacterial lineage across pregnancies is rarely documented. We describe two preterm siblings born one year apart who developed\n                        <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                        sepsis caused by clonally related strains.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Case Summary<\/jats:title>\n                      <jats:p>\n                        Two female infants were born preterm, 1 year apart, at 26 weeks and 4 days and 30 weeks and 3 days of gestation, respectively, following prolonged premature rupture of membranes. Both infants were evaluated for early-onset sepsis at birth with blood cultures and administered empiric ampicillin and gentamicin; initial blood cultures were sterile, and antibiotics were discontinued after 24 h. At 7 days of age, each infant developed new clinical signs of infection, and both were diagnosed with\n                        <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                        bacteremia. Both infants recovered after treatment with intravenous antibiotics. Whole-genome sequencing identified the isolates as O15:K52:H18, sequence type 69 (ST69), differing by only a few single nucleotide polymorphisms.\n                      <\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>\n                        These cases suggest recurrent vertical transmission of a pathogenic\n                        <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                        lineage leading to neonatal infection arising just beyond the immediate newborn period.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00221-25","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:46:02Z","timestamp":1780094762000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Clonally related\n                    <i>Escherichia coli<\/i>\n                    ST69 causing neonatal sepsis in preterm siblings born 1 year apart"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-4683","authenticated-orcid":true,"given":"Dustin D.","family":"Flannery","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Neonatology, Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, University of Pennsylvania Perelman 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