{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:53:07Z","timestamp":1785412387267,"version":"3.56.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["ASM Case Rep"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Bedaquiline\u2019s (BDQ) incorporation into the recommended treatment for drug-resistant tuberculosis (DR-TB) has ushered in a new era of highly effective, shorter course, all-oral regimens. Unfortunately, as the uptake of BDQ-based regimens has increased, so has the emergence of BDQ resistance. In a recent\n                      <jats:italic toggle=\"yes\">ASM Case Reports<\/jats:italic>\n                      article, M. Richard-Greenblatt, R. Bagga, C. Duncan, M. J. Billick, et al. (ASM Case Rep 2:e00126-25, 2025,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/asmcr.00126-25\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/asmcr.00126-25<\/jats:ext-link>\n                      ) reported on a patient with treatment-emergent extensively drug-resistant (XDR) TB, whose isolate harbored a novel loss-of-function\n                      <jats:italic toggle=\"yes\">pepQ<\/jats:italic>\n                      mutation, with resulting BDQ resistance. This commentary briefly highlights the benefits of BDQ-based DR-TB therapy, while also reviewing data related to the growing challenge posed by BDQ resistance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/asmcr.00228-25","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:11:47Z","timestamp":1777900307000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Bedaquiline resistance: a predictable consequence of a game-changing drug?"],"prefix":"10.1128","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-5643","authenticated-orcid":true,"given":"Ronald","family":"Lubelchek","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mf9x671","id-type":"ROR","asserted-by":"publisher"}],"name":"Cook County Department of Public Health","place":["Forest Park, USA"]},{"id":[{"id":"https:\/\/ror.org\/05626m728","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, John H. Stroger, Jr. Hospital of Cook County","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/asmcr.00126-25"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-3004-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv054"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01418-13"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz052"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06331-8"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119430"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02078-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00144-0"},{"key":"e_1_3_1_11_2","unstructured":"World Health Organization. 2025. WHO consolidated guidelines on tuberculosis. Module 4: treatment and care. World Health Organization Geneva"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202503-0679LE"},{"key":"e_1_3_1_13_2","unstructured":"World Health Organization. 2025. Global tuberculosis report 2025. World Health Organization Geneva"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02544-2020"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296448"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01719-2016"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00498-X"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-11067-2"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00470-9"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202506-1489OC"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01611-09"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102135"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2008.08.003"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/0118761429314641240815080447"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00753-16"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00159-19"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaf303"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0002283"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001721"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3108"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01412-21"}],"container-title":["ASM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00228-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/asmcr.00228-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:01:25Z","timestamp":1783429285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/asmcr.00228-25"}},"subtitle":[],"editor":[{"given":"Nicholas M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,7]]}},"alternative-id":["10.1128\/asmcr.00228-25"],"URL":"https:\/\/doi.org\/10.1128\/asmcr.00228-25","relation":{},"ISSN":["2996-2684"],"issn-type":[{"value":"2996-2684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00228-25"}}