{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:09Z","timestamp":1790166489663,"version":"4.1.0"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We found that<jats:italic>Borrelia burgdorferi<\/jats:italic>-vaccinated gamma interferon-deficient (IFN-\u03b3<jats:sup>0<\/jats:sup>) mice challenged with<jats:italic>B<\/jats:italic>.<jats:italic>burgdorferi<\/jats:italic>developed prominent chronic destructive osteoarthropathy. When these mice were treated with anti-tumor necrosis factor alpha (TNF-\u03b1) antibody, the severity of the destructive osteoarthritis was enhanced and affected the mobility of the animals. In addition, extensive swelling of the hind paws occurred. In contrast, treatment of<jats:italic>B<\/jats:italic>.<jats:italic>burgdorferi<\/jats:italic>-vaccinated, challenged IFN-\u03b3<jats:sup>0<\/jats:sup>mice with recombinant TNF-\u03b1 (rTNF-\u03b1) inhibited the development of arthritis, including swelling of the hind paws. Moreover, treatment of vaccinated, challenged IFN-\u03b3<jats:sup>0<\/jats:sup>mice with anti-TNF-\u03b1 inhibited fourfold the production of an antibody that kills<jats:italic>B<\/jats:italic>.<jats:italic>burgdorferi<\/jats:italic>, while treatment of vaccinated, challenged IFN-\u03b3<jats:sup>0<\/jats:sup>mice with rTNF-\u03b1 slightly elevated the level of the borreliacidal antibody. These results suggest that the level of TNF-\u03b1 directly or indirectly regulates the production of borreliacidal antibody and the development of vaccine-induced destructive Lyme osteoarthritis. Studies are in progress to determine the mechanism by which TNF-\u03b1-dependent cytokines generate the destructive arthritis.<\/jats:p>","DOI":"10.1128\/cdli.10.1.44-52.2003","type":"journal-article","created":{"date-parts":[[2003,1,9]],"date-time":"2003-01-09T23:04:09Z","timestamp":1042153449000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Destructive Arthritis in Vaccinated Interferon Gamma-Deficient Mice Challenged with<i>Borrelia burgdorferi<\/i>: Modulation by Tumor Necrosis Factor Alpha"],"prefix":"10.1128","volume":"10","author":[{"given":"John A.","family":"Christopherson","sequence":"first","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L.","family":"Munson","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"England","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine"},{"name":"Department of Pathology, Meriter Hospital, Madison, Wisconsin 53715"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Croke","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica C.","family":"Remington","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Molitor","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"DeCoster","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Callister","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory"},{"name":"Department of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Medical Microbiology and Immunology"},{"name":"Bacteriology, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/infdis\/171.2.400","volume":"171","year":"1995","unstructured":"Adams, L. B., C. M. Mason, J. K. Kolls, D. Scollard, J. L. Krahenbuhl, and S. Nelson. 1995. Exacerbation of acute and chronic murine tuberculosis by administration of a tumor necrosis factor receptor-expressing adenovirus. J. Infect. Dis.171:400-405.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/art.1780380202","volume":"38","year":"1995","unstructured":"Arend, W. P., and J. M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor \u03b1 in rheumatoid arthritis. Arthritis Rheum.38:151-160.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/infdis\/162.1.133","volume":"162","year":"1990","unstructured":"Barthold, S. W., D. S. Beck, G. M. Hansen, G. A. Terwilliger, and K. D. Moody. 1990. Lyme borreliosis in selected strains and ages of laboratory mice. J. Infect. Dis.162:133-138.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/infdis\/172.3.778","volume":"172","year":"1995","unstructured":"Barthold, S. W., and M. S. de Souza. 1995. Exacerbation of Lyme arthritis in beige mice. J. Infect. Dis.172:778-784.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_6_2","first-page":"951","volume":"143","year":"1993","unstructured":"Barthold, S. W., M. S. de Souza, J. L. Janotka, A. L. Smith, and D. H. Persing. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am. J. Pathol.143:951-971.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3329-3333.1999"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.2.363-365.1990"},{"key":"e_1_3_2_9_2","first-page":"158","volume":"167","year":"1992","unstructured":"Callister, S. M., R. F. Schell, K. L. Case, S. D. Lovrich, and S. P. Day. 1992. Characterization of the borreliacidal antibody response to Borrelia burgdorferi in humans: a serodiagnostic test. J. Infect. Dis.167:158-164.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","volume":"344","year":"2001","unstructured":"Choy, E. H. S., and G. S. Panayi. 2001. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med.344:907-916.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_11_2","unstructured":"Coyle P. K. 1993. Lyme disease p. 179-183. In S. Manning (ed.) Pathogenesis of Lyme disease. Mosby-Year Book St. Louis Mo."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.658-663.2000"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.3.1109-1113.1992"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/infdis\/169.3.568","volume":"169","year":"1994","unstructured":"Fikrig, E., L. K. Bockenstedt, S. W. Barthold, M. Chen, H. Tao, P. Ali-Salaam, S. R. Telford, and R. A. Flavell. 1994. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J. Infect. Dis.169:568-574.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.7162-7165.2000"},{"key":"e_1_3_2_16_2","first-page":"1516","volume":"93","year":"1991","unstructured":"Girasole, G., G. Passeri, R. L. Jilka, and S. C. Manolagas. 1991. Interleukin-11: a new cytokine critical for osteoclast development. J. Clin. Investig.93:1516-1524.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.160.2.1022","volume":"160","year":"1998","unstructured":"Gross, D. M., A. C. Steere, and B. T. Huber. 1998. T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J. Immunol.160:1022-1028.","journal-title":"J. Immunol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.281.5377.703","volume":"281","year":"1998","unstructured":"Gross, D. M., T. Forsthuber, M. Tary-Lehmann, C. Etling, K. Ito, Z. A. Nagy, J. A. Field, A. C. Steere, and B. Hubner. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science281:703-706.","journal-title":"Science"},{"key":"e_1_3_2_19_2","first-page":"497","volume":"27","year":"2000","unstructured":"Harjacek, M., S. Diaz-Cano, B. A. Alman, J. Coburn, R. Ruthazer, H. Wolfe, and A. C. Steere. 2000. Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis. J. Rheumatol.27:497-503.","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/cyto.1995.0058","volume":"7","year":"1995","unstructured":"Hayes, M. P., S. L. Freeman, and R. P. Donnelly. 1995. IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability. Cytokine7:427-435.","journal-title":"Cytokine"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.206-212.1999"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF02215851","volume":"14","year":"1995","unstructured":"Houssiau, F. A. 1995. Cytokines in rheumatoid arthritis. Clin. Rheumatol.14(Suppl. 2):10-13.","journal-title":"Clin. Rheumatol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.3.618-622.1994"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/art.1780390513","volume":"39","year":"1996","unstructured":"Joosten, L. A. B., M. M. A. Helsen, F. A. J. van de Loo, and W. B. van den Berg. 1996. Anticytokine treatment of established type II collagen-induced arthritis in DBA\/1 mice. A comparative study using anti-TNF\u03b1, anti-IL-1\u03b1\/\u03b2 and anti-IL-1R\u03b1. Arthritis Rheum.39:797-809.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2774-2779.1993"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.4049\/jimmunol.154.4.1770","volume":"154","year":"1995","unstructured":"Keane-Myers, A., and S. P. Nickell. 1995. T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J. Immunol.154:1770-1776.","journal-title":"J. Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.4049\/jimmunol.155.4.2020","volume":"155","year":"1995","unstructured":"Keane-Myers, A., and S. P. Nickell. 1995. Role of IL-4 and IFN-\u03b3 in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol.155:2020-2028.","journal-title":"J. Immunol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2825-2833.1994"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1084\/jem.181.3.1251","volume":"181","year":"1995","unstructured":"Matyniak, J. E., and S. L. Reiner. 1995. T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med.181:1251-1254.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1847-1855.2001"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/infdis\/174.4.739","volume":"174","year":"1996","unstructured":"Padilla, M. L., S. M. Callister, R. F. Schell, G. L. Bryant, D. A. Jobe, S. D. Lovrich, B. K. Du Chateau, and J. R. Jensen. 1996. Characterization of the protective borreliacidal antibody in humans and hamsters after vaccination with a Borrelia burgdorferi outer surface protein A vaccine. J. Infect. Dis.174:739-749.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_32_2","first-page":"510","volume":"77","year":"1992","unstructured":"Piquet, P. F., G. E. Grau, G. Vesin, H. Loetscher, R. Gentz, and W. Leslauer. 1992. Evolution of collagen arthritis in mice is arrested by treatment with anti-tumor necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology77:510-514.","journal-title":"Immunology"},{"key":"e_1_3_2_33_2","first-page":"2555","volume":"28","year":"2001","unstructured":"Rose, C. D., P. T. Fawcett, and K. M. Gibney. 2001. Arthritis following recombinant ospA vaccination for Lyme disease. J. Rheumatol.28:2555-2557.","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/infdis\/163.6.1267","volume":"163","year":"1991","unstructured":"Saez-Llorens, X., H. S. Jafari, K. D. Olsen, H. Nariuchi, E. J. Hansen, and G. H. McCracken, Jr. 1991. Induction of suppurative arthritis in rabbits by Haemophilus endotoxin, tumor necrosis factor-\u03b1, and interleukin-1\u03b2. J. Infect. Dis.163:1267-1272.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.6.1916-1921.1991"},{"key":"e_1_3_2_36_2","first-page":"145","volume":"94","year":"1993","unstructured":"Shingu, M., Y. Nagai, T. Isayama, T. Naono, M. Nobunaga, and Y. Nagai. 1993. The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chrondrocytes and TIMP production by synovial cells and endothelial cells. Clin. Exp. Immunol.94:145-149.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.7326\/0003-4819-90-6-896","volume":"90","year":"1979","unstructured":"Steere, A. C., A. Grbofsky, M. E. Patarroyo, F. J. Winchester, J. A. Hardin, and S. E. Malawista. 1979. Chronic Lyme arthritis: clinical and immunogenetic differentiation from rheumatoid arthritis. Ann. Intern. Med.90:896-901.","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","volume":"107","year":"1987","unstructured":"Steere, A. C., R. T. Schoen, and E. Taylor. 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med.107:725-731.","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1107-1115.1999"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4049\/jimmunol.138.3.775","volume":"138","year":"1987","unstructured":"Thomas, B. M., G. R. Mundy, and J. J. Chambers. 1987. Tumor necrosis factor alpha and beta induce osteoblastic cells to stimulate osteoclast bone resorption. J. Immunol.138:775-779.","journal-title":"J. Immunol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1073\/pnas.89.16.7375","volume":"89","year":"1992","unstructured":"Thorbecke, G. J., R. Shah, C. H. Leu, A. P. Kuruvilla, A. M. Haridson, and M. A. Palladino. 1992. Involvement of endogenous tumor necrosis factor \u03b1 and transforming growth factor \u03b2 during induction of collagen type II arthritis in mice. Proc. Natl. Acad. Sci. USA89:7375-7379.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0306-4530(94)90010-8","volume":"19","year":"1994","unstructured":"Tilders, F. J., R. H. DeRijk, A. M. Van Dam, V. A. Vincent, K. Schotanus, and J. H. Persoons. 1994. Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinology.19:209-232.","journal-title":"Psychoneuroendocrinology."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"9784","DOI":"10.1073\/pnas.89.20.9784","volume":"89","year":"1992","unstructured":"Williams, R. O., M. Feldman, and R. N. Maini. 1992. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. USA89:9784-9788.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.4049\/jimmunol.151.11.6602","volume":"151","year":"1993","unstructured":"Wooley, P. H., J. Dutcher, M. B. Widmer, and S. Gills. 1993. Influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice. J. Immunol.151:6602-6607.","journal-title":"J. Immunol."},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1084\/jem.174.3.593","volume":"174","year":"1991","unstructured":"Yssel, H., M.-C. Shanafelt, C. Sodoerberg, P. V. Schneider, J. Anzola, and G. Peltz. 1991. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J. Exp. Med.174:593-601.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/infdis\/173.1.187","volume":"173","year":"1996","unstructured":"Zeidner, N., M. Dreitz, D. Belasco, and D. Fish. 1996. Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-\u03b1, interleukin-2, and interferon-\u03b3. J. Infect. Dis.173:187-195.","journal-title":"J. Infect. Dis."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.10.1.44-52.2003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.10.1.44-52.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T17:58:01Z","timestamp":1682445481000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.10.1.44-52.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1128\/CDLI.10.1.44-52.2003"],"URL":"https:\/\/doi.org\/10.1128\/cdli.10.1.44-52.2003","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2002-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}