{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:52:07Z","timestamp":1761843127590},"reference-count":23,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Chlamydia trachomatis<\/jats:italic>\n            heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with\n            <jats:italic>C. trachomatis<\/jats:italic>\n            . Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of\n            <jats:italic>C. trachomatis<\/jats:italic>\n            infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.\n          <\/jats:p>","DOI":"10.1128\/cdli.10.3.446-450.2003","type":"journal-article","created":{"date-parts":[[2003,5,8]],"date-time":"2003-05-08T19:08:45Z","timestamp":1052420925000},"page":"446-450","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Cross-Reactivity between\n            <i>Chlamydia trachomatis<\/i>\n            Heat Shock Protein 10 and Early Pregnancy Factor"],"prefix":"10.1128","volume":"10","author":[{"given":"Fotini","family":"Betsou","sequence":"first","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jose\u0301","family":"Borrego","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Anjos","family":"Catry","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Roma\u0303o","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Machado-Caetano","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marie","family":"Sueur","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Mention","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Faille","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Orfila","sequence":"additional","affiliation":[{"name":"Biobanque de Picardie, 16 rue Fernel, 80000 Amiens"},{"name":"Laboratoire d'He\u0301matologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet"},{"name":"Centre de Gyne\u0301cologie Obste\u0301trique, Universite\u0301 de Picardie Jules Verne, 80054 Amiens, France"},{"name":"Centro de Bacteriologia, Instituto Nacional de Sau\u0300de Dr. Ricardo Jorge"},{"name":"Servic\u0327o de Imunologia, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Nova de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm0595-448","volume":"1","year":"1995","unstructured":"Albani, S., E. 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