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Sera from patients with early Lyme disease were screened for borreliacidal activity specific for<jats:italic>B. burgdorferi<\/jats:italic>50772 and OspC antibodies. Seven sera that contained similarly high titers of each response were then chosen randomly and adsorbed with OspC or a truncated OspC (OspC-Dra) containing the 50 amino acids nearest the carboxy terminus. Adsorption with OspC or OspC-Dra completely eliminated the borreliacidal activity in six (86%) of seven sera and significantly decreased the activity in the remaining serum (titer of 10,240 to 1,280). Moreover, OspC antibodies were no longer detected by OspC enzyme-linked immunosorbent assay or in a Western blot that contained native OspC. The findings confirmed that sera from patients with early Lyme disease contain high concentrations of IgM or IgG borreliacidal antibodies that bind a conserved region of OspC.<\/jats:p>","DOI":"10.1128\/cdli.10.4.573-578.2003","type":"journal-article","created":{"date-parts":[[2003,7,9]],"date-time":"2003-07-09T21:36:29Z","timestamp":1057786589000},"page":"573-578","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["C-Terminal Region of Outer Surface Protein C Binds Borreliacidal Antibodies in Sera from Patients with Lyme Disease"],"prefix":"10.1128","volume":"10","author":[{"given":"Dean A.","family":"Jobe","sequence":"first","affiliation":[{"name":"Microbiology Research Laboratory"},{"name":"Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601"},{"name":"Wisconsin State Laboratory of Hygiene and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Lovrich","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory"},{"name":"Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601"},{"name":"Wisconsin State Laboratory of Hygiene and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory"},{"name":"Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601"},{"name":"Wisconsin State Laboratory of Hygiene and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Callister","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory"},{"name":"Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601"},{"name":"Wisconsin State Laboratory of Hygiene and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00005792-199103000-00001","volume":"70","year":"1991","unstructured":"Agger, W. 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