{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T15:24:48Z","timestamp":1699370688452},"reference-count":30,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Dysregulation of immune responses to intestinal exogenous antigens contributes to the pathogenesis of inflammatory bowel disease, but the specific antigen responsible for the pathogenesis of inflammatory bowel disease is unknown. We measured serum antibody titers against\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            antigens. Immunoglobulin G (IgG) and IgG subclass anti-\n            <jats:italic>C. elegans<\/jats:italic>\n            antibodies in serum samples from 29 patients with ulcerative colitis, 30 patients with Crohn's disease, 7 patients with intestinal Behc\u0327et's disease, and 11 healthy controls were measured by enzyme-linked immunosorbent assay. Serum IgG and IgG2 antibody titers against\n            <jats:italic>C. elegans<\/jats:italic>\n            were significantly higher in patients with inflammatory bowel disease than in controls. Antibody levels were not affected by age, gender, disease activity, extent of disease, or small bowel involvement. The anti-\n            <jats:italic>C. elegans<\/jats:italic>\n            antibody titer was significantly lower in patients with Crohn's disease taking mesalazine or sulfasalazine than in patients not taking these drugs. The increased immune responses to\n            <jats:italic>C. elegans<\/jats:italic>\n            found in patients with inflammatory bowel disease reflect dysregulated immune responses to enteric antigens, which might play a role in the pathogenesis of inflammatory bowel disease.\n          <\/jats:p>","DOI":"10.1128\/cdli.10.5.856-861.2003","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T17:05:04Z","timestamp":1063127104000},"page":"856-861","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Distinct Elevation of Levels of Anti-\n            <i>Caenorhabditis elegans<\/i>\n            Antibody in Sera of Patients with Inflammatory Bowel Disease"],"prefix":"10.1128","volume":"10","author":[{"given":"Nobuhide","family":"Oshitani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hato","sequence":"additional","affiliation":[{"name":"Second Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Second Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/gut.38.3.384","volume":"38","year":"1996","unstructured":"Bansi, D. 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