{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T19:41:29Z","timestamp":1700163689772},"reference-count":50,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Immunoglobulin G (IgG) antibodies to Epstein-Barr virus (EBV) nuclear antigens 2 and 1 (EBNA-2 and EBNA-1, respectively) were studied using sera from healthy individuals of a population with a high incidence of asymptomatic primary EBV infections during infancy or childhood in Japan. Two CHO-K1 cell lines expressing EBNA-2 and EBNA-1 were used for anticomplement and indirect immunofluorescence assays. The positivity rate for EBNA-2 IgG rose in the 1- to 2-year age group, increased and remained at a plateau (\u223c45%) between 3 and 29 years of age (3- to 4-, 5- to 9-, 10- to 14-, and 15- to 29-year age groups), and then reached 98% by age 40 (\u226540-year age group). Both seropositivity for EBNA-1 and seropositivity for EBNAs in Raji cells (EBNA\/Raji) were detected in the 1- to 2-year age group, remained high, and finally reached 100% by age 40. The geometric mean titer (GMT) of EBNA-2 IgG reached a plateau in the 5- to 9- and 10- to 14-year-old groups and remained elevated in the older age groups (15 to 29 and \u226540 years). The GMT of EBNA-1 IgGs increased to a plateau in the 1- to 2-year-old group and remained unchanged in the older age groups. The GMT of EBNA\/Raji IgGs also reached a plateau in the 1- to 2-year-old group, remained level throughout the 3- to 14-year age groups, and decreased in the 15- to 29-year-olds. EBNA-2 IgGs emerged earlier than EBNA-1 IgGs in 8 of 10 patients with infectious mononucleosis, who were between 1 and 27 years old, and declined with time in three of eight cases. These results suggest that EBNA-2 IgG antibodies evoked in young children by asymptomatic primary EBV infections remain elevated throughout life, probably because of reactivation of latent and\/or exogenous EBV superinfection.<\/jats:p>","DOI":"10.1128\/cdli.11.1.123-130.2004","type":"journal-article","created":{"date-parts":[[2004,1,11]],"date-time":"2004-01-11T00:18:20Z","timestamp":1073780300000},"page":"123-130","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection"],"prefix":"10.1128","volume":"11","author":[{"given":"Shizuko","family":"Harada","sequence":"first","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease 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and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Eda","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National 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113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Ito","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Ban","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kuranari","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, 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113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640"},{"name":"Department of Pediatrics, Kanagawa Prefecture Nursing School Hospital, Yokohama City, Kanagawa 235-0022"},{"name":"Department of Autoimmune Diseases and Rheumatology, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-0034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Herpesvirus Laboratory, Department of Virology I"},{"name":"Infectious Disease Surveillance Center"},{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, 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