{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:58:57Z","timestamp":1761893937821},"reference-count":20,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>D8\/17, an alloantigen found on B lymphocytes, has been reported to be elevated in patients susceptible to rheumatic fever and may be associated with autoimmune types of neuropsychiatric disorders. The pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococci model is a putative model of pathogenesis for a group of children whose symptoms of obsessive-compulsive disorder and Tourette's disorder (TD) are abrupt and may be triggered by an infection with group A streptococci. As a test of this model, we have examined D8\/17 levels on the B cells of patients with TD and acute rheumatic fever (ARF) along with those on the B cells of normal controls by flow cytometry. We have utilized several different preparations of D8\/17 antibody along with a variety of secondary antibodies but have been unable to show an association with an elevated percentage of D8\/17-positive, CD19-positive B cells in either ARF or TD. We did find, however, that the percentages of CD19-positive B cells in ARF and TD patients were significantly elevated compared to those in normal controls. Group A streptococcal pharyngitis patients also had an elevated percentage of CD19 B cells, however. These studies failed to confirm the utility of determining the percentage of B cells expressing the D8\/17 alloantigen in ARF patients or our sample of TD patients. In contrast, the percentage of CD19-positive B cells was significantly elevated in ARF and TD patients, as well as group A streptococcal pharyngitis patients, suggesting a role for inflammation and\/or autoimmunity in the pathogenesis of these disorders.<\/jats:p>","DOI":"10.1128\/cdli.11.2.330-336.2004","type":"journal-article","created":{"date-parts":[[2004,3,10]],"date-time":"2004-03-10T20:13:13Z","timestamp":1078949593000},"page":"330-336","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["D8\/17 and CD19 Expression on Lymphocytes of Patients with Acute Rheumatic Fever and Tourette's Disorder"],"prefix":"10.1128","volume":"11","author":[{"given":"Julie L.","family":"Weisz","sequence":"first","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy H.","family":"Augustine","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Bale","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jubel F.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenise","family":"Jensen","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd Y.","family":"Tani","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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