{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:44:56Z","timestamp":1781275496397,"version":"3.54.1"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Recurrent or chronic adenotonsillar infections mainly affect children and frequently involve otherwise healthy subjects. Therefore, having excluded systemic immunological deficiencies, this disease may be due to a local dysfunction of the epithelial structures at either the rhino or oropharyngeal level. The aim of the present investigation was to analyze structural and immunological aspects of tonsils and adenoids in subjects who underwent adenotonsillectomy because of recurrent inflammatory episodes with fever. Histological studies and analyses of the cytokine patterns were carried out in palatine tonsils and adenoid samples from 105 patients who underwent adenoidectomy and bilateral extracapsular tonsillectomy for chronic inflammatory hypertrophy of these organs; 46 of the 105 cases examined presented hyperkeratosis of the crypt epithelium; in the remaining 59, the epithelium was hyperplastic with no signs of keratosis. Scanning electron microscopy revealed a continuous epithelial surface of polygon-shaped flattened cells with fissures towards the cryptic depressions. Titration of interleukin-1\u03b2 and tumor necrosis factor alpha in serum and tissues demonstrated higher concentrations in the adenotonsillar specimens, whereas the rise in interleukin-6 was more modest.<\/jats:p>","DOI":"10.1128\/cdli.11.6.1154-1157.2004","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T18:37:49Z","timestamp":1100198269000},"page":"1154-1157","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Structural and Immunological Characteristics of Chronically Inflamed Adenotonsillar Tissue in Childhood"],"prefix":"10.1128","volume":"11","author":[{"given":"Desiderio","family":"Passa\u0300li","sequence":"first","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Damiani","sequence":"additional","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Cesare","family":"Passa\u0300li","sequence":"additional","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Maria","family":"Passa\u0300li","sequence":"additional","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Boccazzi","sequence":"additional","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Bellussi","sequence":"additional","affiliation":[{"name":"Ear-Nose-Throat Department, University of Siena Medical School Policlinico Le Scotte, Siena"},{"name":"Paediatric Department, University of Milan Medical School, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"88","volume":"5","year":"1996","unstructured":"Alms, W. J., L. B Elwert, and B. White. 1996. Simultaneous quantification of cytokine mRNAs by reverse transcriptase-polymerase chain reaction using multiple internal standard cRNAs. Diagn. Mol. Pathol.5:88-97.","journal-title":"Mol. Pathol."},{"key":"e_1_3_1_3_2","first-page":"127","volume":"32","year":"1969","unstructured":"Awaya, K. 1969. The aging of secondary nodules in the relation of the postnatal development and involution of the human palatine tonsils. Acta Haematol. Jpn.32:127-134.","journal-title":"Acta Haematol. Jpn."},{"key":"e_1_3_1_4_2","first-page":"95","volume":"12","year":"1992","unstructured":"Bellussi, L., S. Norscini, E. Gaudio, and D. Passali. 1992. Modificazioni istomorfologiche indotte da flogosi tonsillari ricorrenti. Acta Otorinol. Ital.12:95-106.","journal-title":"Acta Otorinol. Ital."},{"key":"e_1_3_1_5_2","first-page":"80","year":"1992","unstructured":"Bernstein, J. M., S. Sendor, and J. Wactawski-Wende. 1992. Antigen-presenting cells in the nasopharyngeal tonsil. 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Otorhinolaryngol."}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.11.6.1154-1157.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.11.6.1154-1157.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:34:49Z","timestamp":1627590889000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.11.6.1154-1157.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1128\/CDLI.11.6.1154-1157.2004"],"URL":"https:\/\/doi.org\/10.1128\/cdli.11.6.1154-1157.2004","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"2004-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}