{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T14:12:12Z","timestamp":1648995132500},"reference-count":12,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare heterogeneous primary immune deficiency. We describe a patient with HIGM characterized by skewed production of serum IgG subclasses and normal somatic hypermutation. This case may represent a subgroup of HIGM type 4 that is characterized by a biased switching to the V-region proximal constant regions.<\/jats:p>","DOI":"10.1128\/cdli.11.6.1192-1193.2004","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T18:37:49Z","timestamp":1100198269000},"page":"1192-1193","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Biased Immunoglobulin G (IgG) Subclass Production in a Case of Hyper-IgM Syndrome"],"prefix":"10.1128","volume":"11","author":[{"given":"G. R.","family":"McLean","sequence":"first","affiliation":[{"name":"The Biomedical Research Centre, University of British Columbia"},{"name":"Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Miller","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre, University of British Columbia"},{"name":"Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Schrader","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre, University of British Columbia"},{"name":"Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Junker","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre, University of British Columbia"},{"name":"Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.7679801","volume":"259","year":"1993","unstructured":"Allen, R. C., R. J. Armitage, M. E. Conley, H. Rosenblatt, N. A. Jenkins, N. G. Copeland, M. A. Bedell, S. Edelhoff, C. M. Disteche, D. K. Simoneaux, et al. 1993. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science259:990-993.","journal-title":"Science"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0090-1229(89)90203-1","volume":"51","year":"1989","unstructured":"Aucouturier, P., C. Lacombe, C. Bremard, Y. Lebranchu, M. Seligmann, C. Griscelli, and J. L. Preud'Homme. 1989. 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