{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:21:51Z","timestamp":1791390111346,"version":"4.3.3"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 \u00b1 9271 pre-partial thymectomy and 33157 \u00b1 8479 post-partial thymectomy in 11 paired patients (\n            <jats:italic>P<\/jats:italic>\n            = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days \u00b1 5.8 days. Another group of 8 children had 30384 \u00b1 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.\n          <\/jats:p>","DOI":"10.1128\/cdli.12.5.563-565.2005","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T17:23:00Z","timestamp":1115313780000},"page":"563-565","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Levels of Recent Thymic Emigrant Cells Decrease in Children Undergoing Partial Thymectomy during Cardiac Surgery"],"prefix":"10.1128","volume":"12","author":[{"given":"Ashish B.","family":"Madhok","sequence":"first","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chandrasekran","sequence":"additional","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Parnell","sequence":"additional","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mysore","family":"Gandhi","sequence":"additional","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Pahwa","sequence":"additional","affiliation":[{"name":"North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"322","volume":"70","year":"1987","unstructured":"Brearley, S., T. 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Generation of functional thymocytes in the human adult. Immunity10:569-575.","journal-title":"Immunity"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1073\/pnas.96.4.1536","volume":"96","year":"1999","unstructured":"Kong, F. K., C. L. Chen, A. Six, R. D. Hockett, and M. D. Cooper. 1999. T-cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T-cell pool. Proc. Natl. Acad. Sci. USA.96:1536-1540.","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jaci.2004.01.766","volume":"113","year":"2004","unstructured":"Markert, M. L., et al. 2004. Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. J. Allergy Clin. Immunol.113:734-741.","journal-title":"J. Allergy Clin. 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