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Here, we present direct evidence that adoptive transfer of enriched CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells from these mice can prevent the development of arthritis in<jats:italic>Borrelia<\/jats:italic>-vaccinated and challenged mice. These findings establish a major role for CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>T cells in the prevention of arthritis in<jats:italic>Borrelia<\/jats:italic>-vaccinated and challenged animals.<\/jats:p>","DOI":"10.1128\/cdli.12.6.786-792.2005","type":"journal-article","created":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T17:28:10Z","timestamp":1118078890000},"page":"786-792","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["CD4<sup>+<\/sup>CD25<sup>+<\/sup>T Cells Prevent Arthritis Associated with<i>Borrelia<\/i>Vaccination and Infection"],"prefix":"10.1128","volume":"12","author":[{"given":"Dean T.","family":"Nardelli","sequence":"first","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Cloute","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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Kevin","family":"Luk","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Torrealba","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Callister","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene"},{"name":"Departments of Comparative Biomedical Sciences"},{"name":"Bacteriology"},{"name":"Medical Microbiology and Immunology"},{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.184.2.387","volume":"184","year":"1996","unstructured":"Asano, M., M. 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