{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:40:43Z","timestamp":1725622843566},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>The pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-alpha in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool IL-6 and TNF-alpha concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and &lt; 0.001, respectively) or in uninfected children (P &lt; 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-alpha in stool.<\/jats:p>","DOI":"10.1128\/cdli.2.4.492-495.1995","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:43:35Z","timestamp":1578336215000},"page":"492-495","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Cytokines in the stools of children with complicated shigellosis"],"prefix":"10.1128","volume":"2","author":[{"given":"T","family":"Azim","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Halder","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Sarker","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hamadani","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Qadri","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Salam","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Sack","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Albert","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.2.4.492-495.1995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.2.4.492-495.1995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:06:40Z","timestamp":1645596400000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.2.4.492-495.1995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1128\/cdli.2.4.492-495.1995"],"URL":"https:\/\/doi.org\/10.1128\/cdli.2.4.492-495.1995","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]},"assertion":[{"value":"1995-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}