{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T21:25:05Z","timestamp":1766697905336},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up-regulation of some immune parameters such as the CD4(+)-CD8+ cell-dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and\/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy.<\/jats:p>","DOI":"10.1128\/cdli.2.4.503-505.1995","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:43:37Z","timestamp":1578336217000},"page":"503-505","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias"],"prefix":"10.1128","volume":"2","author":[{"given":"I","family":"Munno","sequence":"first","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Marinaro","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gesario","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Cannuscio","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Michel","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Paulling","sequence":"additional","affiliation":[{"name":"Istituto di Microbiologia, University of Bari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.2.4.503-505.1995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.2.4.503-505.1995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:06:39Z","timestamp":1645596399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.2.4.503-505.1995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1128\/cdli.2.4.503-505.1995"],"URL":"https:\/\/doi.org\/10.1128\/cdli.2.4.503-505.1995","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]},"assertion":[{"value":"1995-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}